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Hgcl2 에 의한 다클론성 활성화에 의해 나타나는 생쥐의 면역반응 변화에 미치는 파치균 다당류의 영향
문창규(Chang Kiu Moon),목명수(Myung Soo Mock),전선덕(Sun Duck Chun),김진형(Jin Hyoung Kim),김강석(Kang Suk Kim),최청하(Chung Ha Choi),황지원(Ji Won Whang) 한국응용약물학회 1994 Biomolecules & Therapeutics(구 응용약물학회지) Vol.2 No.4
Repeated injections of low-doses of mercuric chloride in rats or mice induce polyclonal activation which includes the induction of anti-glomerular basement membrane (GBM) antibodies and circulating immune complex and it results in nephritis. Because this disease is autoimmune mediated disease resulted from immune dysfunction, immunomodulators are used to control the symptoms or to cure the disease. Irpex lacteus Fr. is a kind of new medicinal fungus. The polysaccharide fraction extracted from submerged fermentation of Irpex lacteus Fr. decreased the serum agglutinin, serolysin and IgM plaque forming cells in normal mice. The hitherto obtained clinical results suggested that it significantly improved the oligourea, edema, and hypertension in patients who have nephritis. To elucidate the action-mechanisms of Irpex lacteus Fr., we established the experimental model of HgCl₂ induced polyclonal activation by intraperitoneal administrations of HgCl₂ to mice. To assess the immunomodulating effect of lrpex lacteus fraction, we investigated its effects on the mitogen induced proliferation and IgM PFC counts of splenic lymphocytes in mice during the treatment of HgCl₂. The Irpex lacteus polysaccharide reduced the abnormally increased mitogen induced lymphocyte proliferation and IgM PFCs to almost normal levels. And the Irpex lacteus polysaccharides prevented the increasement of serum immunoglobulin level induced by HgCl₂. These data suggested that the Irpex lacteus polysaccharides might have the immunomodulating activity to prevent and /or improve the HgCl₂ induced autoimmune disease.
Lewis Lung Carcinoma(LLC) 이식 생쥐에 있어서 천연운지 단백다당체(Copolang)의 면역조절활성
문창규(Chang Kiu Moon),임철홍(Cheol Hong Lim),목명수(Myung Soo Mock),양경미(Kyung Mee Yang),한혜승(Hye Seung Han),최재영(Jae Young Choi) 대한약학회 1993 약학회지 Vol.37 No.1
Immune functions of mice bearing Lewis Lung Carcinoma (LLC) were significantly suppressed when evaluated with mitogen responsiveness, IL-2 production and non-specific suppressor activity. Based on these immunosuppressive characteristics of LLC bearing mice, immunomodulating activates of Copolang were investigated in this model. After 15 days of LLC inoculation, Copolang was intraperitoneally administered for 7 consecutive days with doses of 20 or 200 mg/kg. Immune functions were evaluated 3 days after the final administration of Copolang. The results showed that the growth of LLC solid tumor was not inhibited by Copolang. But, mitogens-induced proliferation, IL-2 production and responsiveness to recombinant IL-2 of splenocytes were significantly augmented by the treatment of Copolang. However suppressor cell activity was not affected by Copolang. These results indicate that Copolang expresses potent immunomodulating activates through the augmentations of IL-2 production and responsiveness to recombinant IL-2, which have been generally known to be suppressed in tumor bearing mice, without affecting the growth of tumor.