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- 저자 : 류왕성 ( Lyu Wang Seong ) (검색결과 2 건)
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고콜레스테롤 식이가 Spontaneously Hypertensive Rat의 체내지질과 항산화성 영양소 상태에 미치는 영향
유언호 ( Yu Eon Ho ),류왕성 ( Lyu Wang Seong ),김현대 ( Kim Hyeon Dae ),유재격 ( Yu Jae Gyeog ),최영선 ( Choe Yeong Seon ),이희숙 ( Lee Hui Sug ),조성희 ( Jo Seong Hui ) 대한내과학회 1993 대한내과학회지 Vol.44 No.5
Backgrounds: Hypertension and hypercholesterolemia are two of the most important risk factors for atherosclerosis and cardiovascular morbidity. The mechanism by which hypertension and hypercholesterolemia accelerates atherosclerosis is still uncertain. Methods: To investigate the effect of high cholesterol diet on lipid and antioxidant nutritent status in spontaneously hypertensive rat (SHR), SHRs and Wistar rats were fed diets with or without 2% cholesterol and 0.3% Na-taurocholate for 6 months. Results: SHRs became apparently hypertensive after 2 months of feedings, when their systolic pressure was over 180 mmHg. Heart weight-to-body weight ratios of SHRs were significantly higher than those of Wistar rats. Levels of serum total cholesterol were increased about two-folds and those of liver, ten-folds in both SHRs and Wistar rats by dietary cholesterol. Serum HDL-cholesterol of SHRs were significantly lower than those of Wistar rats and HDL·/total cholesterol. Serum TG levels were not changed, but liver levels increased by dietary cholesterol and lower in SHRs. Serum TBARS levels were higher in SHRs, but little changed by dietary cholesterol. Liver levels appeared to be higher in SHRs and cholesterol groups. Serum and liver vitamin E levels were lower in SHR. Serum vitamin A levels were little changed, but liver contents were somewhat decreased in SHRs and remarkably reduced by dietary cholesterol. Conclusions: It is concluded that hypertension and hypercholesterolemia, individually, result in accumulation of lipid peroxide as well as consumption of body tocopherol and retinol, which can be further augmented by coexistence of two abnormal conditions.
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이향주 ( Lee Hyang Ju ),민철홍 ( Min Cheol Hong ),박승호 ( Park Seung Ho ),김상욱 ( Kim Sang Ug ),강응택 ( Kang Eung Taeg ),류왕성 ( Lyu Wang Seong ),유언호 ( Yu Eon Ho ),김현태 ( Kim Hyeon Tae ) 대한내과학회 1992 대한내과학회지 Vol.42 No.4
To evaluate the change of serum lipid profiles in Korean, serum levels of lipids and lipoproteins were measured in 2300 persons including 727 healthy normal controls and patients with various diseases in 1989-90. The present results compared with preveious studies were as follows. 1) The mean serum lipids and lipoprotein levels in normal controls were 672.2±221.6 ㎎/㎗ for total lipid, 207.8±47.8 ㎎/㎗ for phospholipid, 219.3±62.5 ㎎/㎗ for total cholesterol, 144.5±55.5 ㎎/㎗ for LDL cholesterol, 42.0±13.8 ㎎/㎗ for HDL cholesterol, 171.4±144.7 ㎎/㎗ for triglyceride, 32.4±8.0% for lipoprotein α, 16.5±8.6% for lipoprotein preβ, 51.0±9.3% for lipoprotein β. 2) The mean serum lipids and lipoprotein levels in patients with hypertension were 704.2±189.5 ㎎/㎗ for total lipid, 216.4±44.2 ㎎/㎗ for phospholipid, 237.0±63.1 ㎎/㎗ for total cholesterol, 161.4±60.8 ㎎/㎗ for LDL cholesterol, 42.6±13.6 ㎎/㎗ for HDL cholesterol, 174.8±126.7 ㎎/㎗ for triglyceride, 31.2±7.5% for lipoprotein α, 16.4±9.1% for lipoprotein preβ, 52.5±9.2% for lipoprotein β. 3) The mean serum cholesterol levels, in particular LDL cholesterol, rose after forth decade, reaching thier peak between 50 and 60 years. 4) Type Ⅱa was the predominant lipoprotein pattern in most of cardiovascular diseases in Korea such as hypertension, cerebrovascular accident, ischemic heart disease and diabetes mellitus. 5) The mean serum cholesterol levels in normal controls and hypertensives have increased significantly since 1973. Although the incidence of coronary heart disease is still low in Korea, it is evident that it s increasing at a rapid speed, because the risk of hypercholesterolemia increases exponentially according to the number and severity of other concurrent risk factors.
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