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- 저자 : 뢰영성 ( Yong Sung Loi ) (검색결과 1 건)
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뢰영성 ( Yong Sung Loi ),권영모 ( Kwon Yeong Mo ),박종흠 ( Park Jong Heum ),박선동 ( Park Seon Dong ) 대한본초학회 2003 大韓本草學會誌 Vol.18 No.3
N/A objectives: Exposure to oxidant molecules can generate reactive oxigen species(R0S; for example, H₂O₂, O₂-, OH .). These free radicals can alter DNA, proteins and membrane phospholipids. ROS are responsible for aging and many diseases including cancer, neurodegenerative diseases and cardiovascular diseases. Thus, to prevent against celluar damages associated with oxidative stress, antioxidants are important and many research about antioxidants are being conducted over the world. methods: This study was performed to research the antioxidant activities of Insamgobonwhan(IG) and its component groups in vitro, so intended to know the possibility of Insamgobonwhan(1G) as drug which can prevent aging. The experimental group was divided into 4 groups: Imsamgobonwhan(IG), two dong-two jiwhang(IG-1; 麥門冬, 天門冬, 熱地黃, 生地黃), two dong(IG-2; 麥門冬, 天門冬) and two jiwhang(IG-3; 熱地黃, 生地黃). results: 1. All experimental groups had significant antioxidant activity in linoleic acid system on concentration dose--dependently in comparison with control group. But IG and IG-2 have more effect than IG-1 and IG-3 relatively. 2. DPPH radical scavenging experiment and inhibitory effect experiment on superoxide generation in xanthine-xanthine oxidase system showed that all experimental groups had a dose-dependent effect. But IG and IG--1 had more effect than IG-2 and IG-3. 3. Inhibitory effect experiment on superoxide generation induced by xanthine-xanthine oxidase system showed that all experimental groups had a dose-dependent effect. But IG and IG-1 had more effect than IG-2 and IG-3. 4. Inhibitory effect experiment on lipid peroxidation reaction in H₂O₂-Fe²system showed that all experimental groups had a dose--dependent effect. But IG and IG--1 had more effect than IG-2 and IG-3. 5. Experiment on lipid peroxidation removal effect showed that all experimental groups had a dose-dependent effect. But IG and IG-2 have more effect than IG-1 and IG-3. 6. Experiment on glutathion activity effect showed that all experimental groups had some effect. But each groups had no significant difference. 7. Experiment on catalase activity effect showed that all experimental groups had some effect. But each groups had no significant difference. conclusion: These results showed that IG has an antioxidant activity, so it seems to have some anti-aging effect. From comparisons of each experimental groups, IG`s antioxidant effect is likely to be associated with IG-1 mostly.
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