http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
전립선암에서 인체신경줄기세포를 이용한 Cystosine Deaminase 자살유전자 세포치료법 개발
송윤섭(Yun Seob Song),이홍준(Hong Jun Lee),두승환(Seung Whan Doo),양원재(Won Jae Yang),김대홍(Dae Hong Kim),이상진(Sang Jin Lee),김승업(Seung Up Kim) 대한비뇨기종양학회 2010 대한비뇨기종양학회지 Vol.8 No.3
Purpose: Stem cells have migration ability toward cancer cells and therapeutic genes can be easily transduced into stem cells with viral vectors. Cystosine deaminase (CD) is the enzyme that transforms the prodrug 5-fluorocytosine to highly toxic drug 5-fluorouracil (5-FU). This study was performed to investigate the migration ability of CD gene transduced human neural stem cells (Hb1.F3-CD) toward prostate cancer after systemic treatment in C57B mice. Materials and Methods: An Hb1.F3 with a retroviral vector encoding v-myc, lacZ was generated and transfected with recombinant retrovirus from the pMSCV-puro/CD. Reverse transcription (RT) was performed to evaluate the expression of CD in Hb1.F3-CD. In vivo migration assay after systemic injection of Hb1.F3-CD was performed in prostate cancer induced C57B mice using molecular magnetic resonance (MR) imaging and immunochemical staining. Results: Transgene expression in CD-hNSCs was demonstrated. In vivo migration ability of CD-hNSCs cells toward TRAMPC2 induced prostate cancer was found using MR imaging and X-gal stain after implantation of HB1.F3-CD in C57B mice. Conclusions: We confirmed the migration ability of HB1.F3-CD toward prostate cancer cells after systemic treatment in C57B mice. This finding may imply a possible novel selective chemotherapeutic strategy against prostate cancer.