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Polymannuronate가 흰쥐의 혈청과 간장조직중의 Leptin에 미치는 영향
김인혜 ( Kim In Hye ),이동수 ( Lee Dong Su ),권지영 ( Kwon Ji Yeong ),권미진 ( Kwon Mi Jin ),남택정 ( Nam Taeg Jeong ) 한국수산과학회 2003 한국수산과학회지 Vol.36 No.6
N/A This study investigated the effects of polymannuronate feeding on cholesterol levels and leptin in the serum and liver of Sprague-Dawely rats. After one week of basal diet feeding, four week old S.D. male rats were fed with polymannuronate. The feeding efficiency of the polymannuronate fed group averaged around 0.27, which was 0.02-0.03 lower than that of the control group, and liver weight, also had a lower increase. The liver tissue tagging of rats by staining fat drops increased in the cholesterol fed group. RIA and RT-PCR were used to determine the expression of leptin in the serum and liver of rats. The polymannuronate fed group had a larger reduction in the serum and liver leptin than the cholesterol fed group. The RT-PCR results showed that leptin mRNA was expressed in the liver. The polymannuronate fed group had a larger reduction in liver leptin mRNA expression than the cholesterol fed group. The above results suggest that feeding of polymannuronate improves the physiological function of rats by changing serum and liver lipid composition and the expression of leptin was repressed at a molecular level.