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RISS 인기검색어
- 검색키워드
- 저자 : 김진규(Jin Kyoou Kim) (검색결과 1 건)
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김종진(Jong Jin Kim),문미경(Mi Kyoung Moon),임학(Hark Rim),김진규(Jin Kyoou Kim),박선자(Seon Ja Park),양상호(Sang Ho Yang),박상은(Sang Eun Park),이시래(Si Rhae Lee) 대한내과학회 1991 대한내과학회지 Vol.41 No.2
The immune response to HB vaccination in ESRD patients has thus far been poor, but a better immune response is seen in patients who have been given reinforced vaccination. We measured anti-HBs seroconversion rates in a total of 100 ESRD patients (HD 60, CAPD 37, and transplantation 3 patients) who were vaccinated with Hepavax®. The results were as follows: 1) The anti-HBs seroconversion rate of 54 anti-HBc positive patients was 44.6%, and that of 46 anti-HBc negative patients 34.8%. 2) Anti-HBs seroconversion rates were 38.3% in the HD group, 43.2% in the CAPD group, and 33.3% in the renal transplantation group. 3) There was a lower anti-HBs seroconversion rate in the group under going a longer of dialysis: 44.4% in the group of less than 1 month period of dialysis and 9.1% in the group who had been on dialysis for 13 to 36 months. 4) Anti-HBs seroconversion rates were 39.1% in 40 ㎍, 3 times vaccination group, 45.6% in 20 ㎍, 3 times vaccination group, and 39.3% in 40 ㎍, 1 or 2 times vaccination group. The seroconverted patients in 40 ㎍, 3 times vaccination group revealed a higher titer and longer sustained anti-HBs in serum. However, anti-HBs seroconversion rates were not different in the 3 groups of various dosages. 5) An anti-HBc negative patient who had revealed low titer of anti-HBs after 3 doses of 20 ㎍, received a kindey transplantation from an HBsAg negative donor and developed acute viral hepatitis B in 10 months. Another anti-HBc positive patient, who had revealed a low titer of anti-HBs after 2 doses of 40 ㎍ but converted into anti-HBs negative in 5 months, showed a high titer of anti-HBs after receiving a renal transplantation from an HBsAg positive donor. These results show that reinforced doses of HB vaccine in ESRD patients were effective in developing a higher titer and longer duration of anti-HBs.
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