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김종석(Jong Seok Kim),최종락(Jong Rak Choi),정철완(Chul Wan Jung),서경(Kyung Seo),김중열(Jung Yeol Kim),성연준(Youn Joon Sung) 대한산부인과학회 2000 Obstetrics & Gynecology Science Vol.43 No.7
Holoprosencephaly(HPE), a common developmental defect affecting the forebrain and cranioface, is etiologically heterogenous. Teratogen, chromosomal anomalies, genetic syndrome, or genetic disorder of non-syndromic HPE are usually accepted as etiology. But the severity of brain and craniofacial malformation are not associated with etiology. Individuals with microform of HPE, who usually have normal cognition and brain imaging, are at the risk of having children with HPE. Several studies on the basis of HPE gene have been performed, which shed valuable insight on normal brain development. As additional HPE genes are identified, more accurate recurrent risk counseling can be given. We experienced a case of recurrent HPE diagnosed by transabdominal ultrasound examinations at 22 weeks' gestation.
심상성 천포창 치료를 위해 cyclophosphamide를 장기간 경구 투여중 발생한 조기난소부전 1예
성연준(Youn Joon Sung),이윤호(Yoon Ho Lee),차동현(Dong Hyun Cha),김중열(Jung Yeol Kim),홍순옥(Soon Oak Hong) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.2
Pemphigus vulgaris is autoimmune disease characterized by acantholysis and blister formation in the skin and mucosa. The introduction of corticosteroids has greatly reduced mortality, and a number of immunosuppressive agents, such as azathioprine and cyclophosphamide are recommended as adjuncts to oral steroids. A 38-year-old female patient of pemphigus vulgaris has been managed with daily oral cyclophosphamide as adjunct to prednisolone for about 11 months, and then transfered to our department due to amenorrhea for 4 months. Hormonal profile of FSH, LH and estradiol revealed in postmenopausal range and follow-up results of hormonal profile were not changed, and amenorrhea continues for total 13 months until now. So we report a case of premature ovarian failure complicated by long-term oral administration of cyclophosphamide.