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      • KCI등재

        자미꾸리 ( 추어 - Misgurnus Anguillicaudatus CANTOR ) 를 사용한 포상기태 뇨반응 및 임신뇨반응에 관한 연구 ( 제1보 )

        김정완(JW Kim) 대한산부인과학회 1961 Obstetrics & Gynecology Science Vol.4 No.2

        1. 저자는 자미꾸리 성어를 실험동물로서 사용하는 새로운 포상기태뇨반응 및 임신뇨반응의 시험법을 고안하여 잠정적으로 『김씨반응』(Kim`s test)이라고 명명하였다. 2. 저자는 자미꾸리 성어에 산란현상을 일으켜 양성으로 반응시킬 Gonadotrophin의 최소량을 1미꾸리 단위(L.U)라고 정하였다. 3. 이 반응을 포상기태뇨 21예 및 악성융모상피종뇨 2예에 시험한 결과 100%의 양성율을 얻어 임신과 감별되었고, 위반응은 대조뇨 즉 46일~100일 임뇨 165예중 8예 즉 4.84%였다. 4. 임부뇨 260예중 234예가 양성으로 반응하여 90.00%이었으며 위반응은 대조인 비임부뇨 229예중 16예 양성으로서 6.98%였다. 5. 이 반응은 단 1회의 시험만으로서 포상기태, 임신 및 비임신을 감별할 수 있었다. The author`s attention was called to the fact that adult female loaches do not spawn until they copulate in spite of carrying a large quantity of eggs around the year, and there is the possibility that an artificial spawning might be brought about by the administration of urine rich in gonadotrophin. In the light of this, the author developed a new test by administering patient`s urine to a loach for the diagnosis of hydatidiform mole and pregnancy, and its value was confirmed by various preliminary studies. The test was applied to 21 cases of hydatidiform mole and two cases of chorionepithelioma malignum, obtaining strongly positive reactions (++) in all cases it made the differentiaion of these conditions from pregnancy possible. In another study, 165 urine specimens from women of 46 to 100 day gestation were tested obtaining trongly positive reactions (++) in only eight specimens, resulting in 4.84% false positivity. Similar test was done utilizing 260 specimens of pregnant women in which 234 specimens (90%) were found to be positive (+) whereas out of 229 specimens of urine of nonpregnant women only 16 (6.98%) reacted positively (+). It was found that one of the most prominent features of this that is test it enabled us to differentiate between pregnancy, non-pregnancy and hydatidiform mole by a single test. In addition, this test is highly reliable and practical in diagnosing early pregnancy. The author temporarily named this test as Kim`s Test.

      • KCI등재

        자미꾸리 ( 추어 - Misgurnus Anguillicaudatus CANTOR ) 를 포상기태 뇨반응 및 임신뇨반응에 관한 연구 ( 2보 )

        김정완(JW Kim) 대한산부인과학회 1962 Obstetrics & Gynecology Science Vol.5 No.4

        Further studies were carried out on the urine test on loaches for the diagnosis of pregnancy and hydatidiform mole, by the method previously described by the author. In the current study, positive reactions(+) were obtained in 108 urine specimens(85.71%) of pregnant women out of 126. Thus, the over all results of the current and previously reported studies showed positive reactions in 342 specimens out of 386, the incidence of positivity being 88,60%. However, seasonal variations were noted in the trsults. i.e., the incidence of positive reactions was 92.41% during spring and summer (between March and August) and 78.89% during fall and winter(between September and Fabruary). False positive reactions were noted in 11 out of 100 specimens from non-pregnant women. Thus the total of 27 urine specimens of non-pregnant women out of 329 in the current and previously reported studies showed positive reactions, the incidence of false positivity being 8.2%. In seven specimens frome eight patients with hydatidiform mole, strongly positive reactions(++) were obtained. Thus, the over all results of the current and previously reported studies showed strong positive reactions in 28 cases out of 29, the incidence of positivity being 96.55%. It was noted that the urine specimens of patients with hydatidiform mole produced the strongest stimulation of spawning in loaches. It was felt that this test was a simple yet very acurate diagnostic test for hydatidiform mole.

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