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Methotrexate 의 D 및 L 체가 사람 임파구 염색체에 미치는 영향에 대하여
김정중(Jeongjoong Kim),고건일(Geonil Ko),정연태(Yoentae Jeong),김재백(Jaebaek Kim) 한국약제학회 1986 Journal of Pharmaceutical Investigation Vol.16 No.4
Sister chromatid exchanges (SCEs) induced by D-methotrexate (MTX) was investigated and compared to L-methotrexate at same doses in cultured PHA activated human lymphocytes. The results is as follows; the frequencies were found to be 11.00±0.31, 13.99±0.27, 16.97±0.32, 21.00±0.43, and 7.85±0.26 in treated with 10^(-6), 10^(-6) Mol D-MTX. L-MTX and the control, respectively. L-MTX was found to be more potent for inducing SCE than D-MTX. The regions generally vulnerable to D -and L-MTX were 1p32 and 1p23 in chromosome 1, 2q21 and 2q31 in chromosome 2, 3q21 and 3p21 in chromosome 3. SCE induced by both D-and L-MTX occurred mostly in the G-light band regions.
HPMCAS 의 pH 의존 용해성에 대한 기전과 약제학적 평가
서순철(Soonchul Seo),고건일(Geonil Ko),김재백(Jaebaek Kim) 한국약제학회 1986 Journal of Pharmaceutical Investigation Vol.16 No.4
For study of pharmaceutical properties of HPMCAS, film made by HPMCAS were tested for dissolution rate, for resistance in acidic solution and for stability under accelerated temperature and humidity condition. And also film coating preparations(VB₂ tablet, VB₂ granule, Cefalexin granule) were tested in vitro and in vivo test. The result is as follows. 1) pH-dependent solubility of HPMCAS was related with their dissociation constant. 2) HPMCAS is stable in accelerated condition and resist in acidic solution. 3) Sustained release part of preparation made by HPMCAS coating are as same pattern as organic solvent system of Eudragit L-90.
영지다당체의 실험적 간경화에 대한 섬유화 억제효과에 대한 연구
김좌진,김재백,고건일,손동환 圓光大學校 藥品硏究所 1996 藥品硏究所報 Vol.11 No.1
This study was carried out to investigate the effects of the water soluble fraction and the ethanol soluble fraction of polysaccharide extracted from Ganoderma lucidum. The experimental hepatic cirrhosis was induced by bile duct ligation/scission (BDL/S) in rats. BDL/S rats in each group were dosed 5 mg/rat/day of the ethanol soluble polysaccharide extracted from Ganoderma lucidum and were dosed 0.5, 2.0, 5.0 or 10 mg/rat/day of the water soluble polysaccharide orally for 4 weeks after the operation. Antifibrotic effects were evaluated by serum biochemical values, hydroxyproline contents in liver, and light microscopical histology of liver. In ethanol soluble polysaccharide extracted from Ganoderma lucidum, the result obtained were as follows; Hydroxyproline and PIlIP contents in liver of 5mg/kg treated group were significantly reduced. In serum test ALT AST values were rather increased. In water soluble polysaccharide extracted from Ganoderma lucidum, the results obtained were as follows; 1) Hydroxyproline contents in liver of 2.0 and 5.0 mg/kg treated group were significantly reduced in dose dependent manner. 2) In serum test, ALT, AST, ALP values in polysaccharide group were lower than BDL/S control group. 3) The hepatic damage such as hepatocellular inflammation, bile duct proliferation and fibrosis was less severe in the livers of 2.0 and 5.0 mg/kg polysaccharide treated rats than BDL/S control groups. These results suggest water soluble polysaccharides from Ganoderma lucidum had the antifibrotic effect on liver cirrhosis induced by BDL/S.
Kim, Jaebaek,Lee, Young Mi,Lee, Sung Hee,Sohn, Dong Hwan 圓光大學校 藥品硏究所 1996 藥品硏究所報 Vol.11 No.1
The in vitro percutaneous absorption of antisense phosphorothioate oligonucleotide (PS-ODN) complementary to TGF-β was reported previously. The purpose of the present study is to find out optimum formulations of PS-ODN available for the wounded skin administration. The effects of three bases, such as pluronic F127 (PF127), fatty alcohol and propylene glycol (FAPG), vaseline (VAS) on PS-ODN release from formulation and its penetration through excised rat skin were investigated. All bases retarded the permeability of PS-ODN through damaged rat skin compaired to water. The fluxs for PS-ODN formulation were increased in the following order; VAS < FAPG < PF127. The permeability of PS-ODN were slightly increased by addition of benzalkonium chloride (BZ). The concentration of PF127 has a profound effect on the viscosity of ointment base. The fluxs and other penetration parameters such as permeability coefficient, diffusion constant, partition coefficient were increased in the following order; 25% < 17% < 20%. Our results suggest that the 20 % PF127 gels can be used as base of PS-ODN, wound healing agent since they exhibit reverse thermal gelation behavior and have good drug release characteristics and low toxicity.