http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : 김은향(Eun H. Kim) (검색결과 1 건)
- 무료
- 기관 내 무료
- 유료
-
Procarbamate계 살충제 benfuracarb의 산화적 활성화 과정을 통한 독성발현
유용만(Yong-Man Yu),김은향(Eun H. Kim),김성문(Songmun Kim),허장현(Jang-Hyun Hur) 한국농약과학회 2003 농약과학회지 Vol.7 No.1
This study was conducted to understand the role of oxidative enzyme cytochrome P₄?? in the bioactivation of benfuracarb and to know metabolites of benfuracarb by cytochrome P₄??. The bimolecular inhibition rate constant (k<SUB>i</SUB>) of benfuracarb on acetylcholinesterase (AChE) was as low as 1.1×10³ M?¹ min?¹, suggesting that benfuracarb should be activated for its toxic action. The potency of benfuracarb on AChE in the oxidase system (cytochrome P₄?? + NADPH) in vitro was 10-fold higher than that of control (cytochrome P₄??). Such a similar result was also found in the oxidase + PBO system. In vivo the I?? of benfuracarb was 22.7 ㎎ ㎏?¹, but pie-treatment of piperonyl butoxide (PBO) reduced the I?? by>100 ㎎ ㎏?¹, This result suggests that cytochrome P4S0 was involved in the activation of benfuracarb. Using microsomal oxidase system, metabolites of benfuracarb were elucidated. Fifty-eight percent of benfuracarb was converted to carbofuran, a major toxic metabolite, in the oxidase system, while only less than two percent of benfuracarb was converted to carbofuran in the oxidase + PBO system. These results also suggest that cytochrome P₄?? was involved in the activation of benfuracarb. Overall results indicate that cytochrome P₄?? could be involved in the bioactivation of benfuracarb to carbofuran.
ScienceON
DBpia연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
