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기니픽 천식 모델에서 난알부민의 감작 방법에 대한 연구
김유영(You Young Kim),김윤근(Yoon Keun Kim),장윤석(Yoon Suk Chang),정재원(Jae Won Jung),조상헌(Sang Heon Cho),민경업(Kyung Up Min),이병재(Byung Jae Lee),이상록(Sang Rok Lee),박흥우(Heung Woo Park),김상헌(Sang Heon Kim),박원서(Weon Se 대한천식알레르기학회 1999 천식 및 알레르기 Vol.19 No.6
Background and objective : The induction of allergic sensitization is the key process of guinea pig asthma model, but few studies has been done on allergen sensitization per se. We performed to investigate the effect of initial sensitization route on asthmatic reactions in response to sub- sequent repeated allergen challenges. Subjects and methods : Thirteen guinea pigs were sensitized with ovalbumin by intraperitoneal injection(group A) and 14 by exposure to aerosolized ovalbumin(group B) on two occasions separated by 1 week. Animals were challenged by inhalation of stepwise increasing concentration of 0.1, 0.5, 1, and 2% ovalbumin every 2 weeks 5 times. We used Penh (enhanced pause) as an index of airway constriction. Allergen inhalation discontinued when an increase of Penh more than 200%, and provocative concentration of ovalbumin causing a 200% increase in Penh was defined as PC200 Bronchoalveolar lavage and histopathological examination of lung tissue was done 24 after last challenge. Results : On first challenge, 11 (85% ) of group A had asthmatic reactions, but only 5 (36% ) of group B did. Geographic mean of PC200 was significantly lower in group A than that of group B(0.26% vs. 1.26 %, p<0.01). On repeated allergen challenge, PC200 of group A was relatively unchanged, but that of group B was much variable. Sensitized guinea pig had increased eosino- phil infiltration in BAL and there are no differences between group A and B in lang pathology. Conclusion : Ovalbumin sensitization by intraperitoneal injection of guinea pig is better than inhalation method in first allergen challenge and unvaried asthmatic reactions on repeated chal- lenges.
영유아천명후 기관지천식으로의 이행에 미치는 부모이 아토피와 기관지과민성의 영향
김윤근(Yoon Keun Kim),고영률(Young Yull Koh),이명현(Muyng Hyun Lee),정진화(Jin Hwa Jung),지영구(Young Koo Jee),조상헌(Sang Heon Cho),민경업(Kyung Up Min),김유영(You Young Kim) 대한천식알레르기학회 1998 천식 및 알레르기 Vol.18 No.4
Background: Many young children suffer from wheezing illness during viral respiratory infection, and some of them experience wheezing many years later and ultimately develop bronchial asthma. It is not clear whether atopy or bronchial hyperresponsiveness in the family is a significant risk factor for asthma in this clinical setting. Objective : To examine the genetic basis for the development of asthma after early childhood wheezing. Materials and methods : A measurement of serum total IgE concentration, skin prick test to common inhalant allergens, and methacholine bronchial provocation test were performed in 29 asthmatic children and their parents, and 22 non-asthmatic children with the past history of wheezing illness during the first three years of age and their parents. A questionnaire was performed to assess the presence of asthma and allergic rhinitis in the parents. Results : Positive skin test response to common inhalant allergens was more prevalent in asthmatics than in non-asthmatics(67.8% vs. 27.2%). Serum total IgE concentration was significantly higher in asthmatics than in non-asthmatics(geometric mean: 173 vs. 83 IU/ ml). Positive skin test response to comman inhalant allergens was more prevalent in parents of asthmatics than in thoae of non-asthmatics(51.7% vs. 25.0%), but serum total IgE level was not different between the two groups(geometric mean: 132 vs. 120 IU/ml). Positive rate of methacholine bronchial provocation test, geometric mean of PC20-methacholine, and BR index were not different between the parents of asthmatics and non-asthmatics (18.1% vs. 13.9%; 164 vs. 180 mg/ml; 1.154+-0.077 vs. 1.055+-0.068, respectively). Conclusion : It is suggested that personal atopy is important in the development of asthma after early childhood wheezing, and parental atopy rather than bronchial hyperresponsiveness is a risk factor for the development of childhood asthma in this clinical setting.
천식 환아의 형제에서 흡입성 항원에 의한 피부반응도 및 기관지과민성과 염색체 11q13 유전형 사이의 연관성
김윤근(Yoon Keun Kim),손지웅(Jee Wong Son),조상헌(Sang Heon Cho),이명현(Myung Hyun Lee),고영률(Young Yull Koh),민경업(Kyung Up Min),김유영(You Young Kim) 대한천식알레르기학회 1998 천식 및 알레르기 Vol.18 No.4
Background: Increased IgE antibody responses to inhalant allergens and bronchial hyperres- ponsiveness are important phenotypes in development of asthma. Although heredity reported to be important in expression of these phenotypes in twin and family studies, genetic factor(s) controlling these phenotypes is unknown. Objective: To evaluate whether genetic factor in chromosome 11q13 may control the expression of IgE responses to common inhalant allergens and bronchial hyperresponsiveness, linkage analysis between these phenotypes and gene marker of chromosome 11q13 was investigated. Material and methods: The phenotyping and genotyping using microsatellite marker (D11S97) were performed in 77 probands with bronchial asthma and 80 their sibs. The linkage analysis between these phenotypes and the genotype was evaluated by affected or quantitative trait locus (QTL) sib-pair analysis. Results: Positive skin test responses to inhalant allergens were 55/77(71.4%) in probands and 44/79(55.6%) in sibs, respectively. Positive bronchial provocation test responses to methacholine were 27/61(44.3%) in sibs, geometric mean of PC20-methacholine were 5.2 mg/ ml in probands and 39.4 mg/ml in sibs, respectively, and slope of dose response curve(mean+- SE, %/mg/ml) were 11.3 +- 3.22 in probands and 1.97 +- 0.5 in sibs, respectively. Of 34 sib-pairs with positive skin test responses to allergens, two D11S97 alleles were shared by 21(61.8% ) sib -pairs, one allele by 11(32.3% ) sib-pairs, and no identical allele by two(5.9% ) sib-pairs. In affected sib-pairs, sharing rate of the alleles was 77.9%, which indicates linkage of the phenotype and genotype(p<0.001). Of 25 sib-pairs with bronchial hyperresponsiveness to methacholine, two D11S97 alleles were shared by seven(28%) sib-pairs, one allele by 11(44%) sib-pairs, and no identical allele by seven(28% ) sib-pairs. In affected sib-pairs, sharing rate of the alleles was 50%, which indicates no linkage between the phenotype and genotype(p) 0.05). Differences of geometric value(mean +- SE) of PC-methacholine and slope of dose response curve(mean +- SE, %/mg/ml) were 1.11+- 0.17 and 8.33+- 3.35 in sib-pairs sharing two alleles, respectively, 0.99 +- 0.14 and 14.27+-5.75 in sib-pairs sharing one allele, respectively, and 0.57+-0.13 and 3.64+-1.62 in sib-pairs sharing no allele, respectively. There was no difference of the above values among the three groups. Conclusion: The expression of skin reactivity to common inhalant allergens was linked to gene marker of chromosome 11q13, not with bronchial responsiveness to methacholine.
김윤근(Yoon Keun Kim),정진화(Jin Hwa Jung),김창근(Chang Keun Kim),고영률(Young Yull Koh),조상헌(Sang Heon Cho),민경업(Kyung Up Min),김유영(You Young Kim) 대한천식알레르기학회 1998 천식 및 알레르기 Vol.18 No.4
Backgronnd: Bronchial asthma is a complex genetic disorder. Although serum IgE level and bronchial hyperresponsiveness are well known to be under genetic control, the influence of genetic factors on basophil releasability has been seldom studied. Objective : The present study was carried out to investigate whether genetic factors may influence the basophil histamine releasability. Materials and methods : We studied 50 children, 32 with atopic asthma (AA) and 18 normal control (NC), and their parents. Suspensions of leukocytes were isolated and stimulated with Ca ionophore and anti-IgE antibody. Then, histamine in the supernatant was as-sayed by an automated fluorometric analyzer. Results : Among the probands, AA children had a significantly higher anti-IgE induced histamine release than NC children. In contrast, Ca ionophore-induced histamine release was similar between the two groups. Ca ionophore-induced or anti-IgE-induced histamine release was not significantly different between parents of AA children and those of NC children. However, the maximal histamine release by Ca ionophore in parents had a significant correlation with that of probands, whereas the values by anti-IgE were not correlated between probands and their parents. Conclusion : We confirmed that basophils from patients with atopic asthma are characterized by a specific increase in IgE-mediated histamine release. The significant correlation of Ca ionophore-induced maximal histamine release between children and their parents suggests that genetic factors may play an important role in the control of non-IgE-mediated relessability from basophils.
증례 / 관상동맥혈관조형술과 심내막조직검사로 증명한 심장과 관성동맥을 침범한 Churg - Strauss 증후군
김상헌(Sang Heon Kim),박흥우(Heung Woo Park),연태진(Tae Jin Yeon),김상훈(Sang Hoon Kim),장윤혜(Yoon Hae Chang),정희(Hee Chung),이병재(Byung Jae Lee),김윤근(Yoon Keun Kim),조상헌(Sang Heon Cho),민경업(Kyung Up Min),김유영(You Young K 대한천식알레르기학회 2000 천식 및 알레르기 Vol.20 No.2
Churg-Strauss syndrome (CSS) is a rare systemic disease characterized by vasculitis and peripheral eosinophilia in patients with an atopic constitution. Cardiac involvement is an important cause of morbidity and mortality in patients with CSS but coronary artery involvement is very rarely documented. We report a case of a 27-years-old female with CSS who had coronary vasculitis. Coronary angiography and endomyocardial biopsy demonstrated coronary vasculitis and cardiac involvement.
증례 / 에폭시수지가 함유된 근관충전제 ( root canal sealer ) 에 의한 접촉 두드러기
김상훈(Sang Hoon Kim),정희(Hee Chung),장윤혜(Yoon Hae Chang),이병재(Byung Jae Lee),김윤근(Yoon Keun Kim),조상헌(Sang Heon Cho),민경업(Kyung Up Min),김유영(You Young Kim) 대한천식알레르기학회 2000 천식 및 알레르기 Vol.20 No.2
Epoxy resin based on Diglycidyl-ether-Bisphenol-A has been commonly used in dental fillings and dentures. Epoxy resin is a well known low molecular weight chemical sensitizer, but contact urticaria from epoxy resin has been infrequently reported despite it's wide use in dental practice. We report a case of a 48-year-old housewife who presented a recurrent episode of perioral erythema and angioedema associated with dental work. These symptoms, which occurred within 2 hours of having dental fillings, were aggravated with repeated dental procedures for a period of several days. Her symptoms improved after removal of dental fillings. Her contact urticaria to epoxy resin was reproduced by patch test with AH26 root canal sealer containing Bisphenol-A type epoxy resin. Delayed type reaction to epoxy resin was also noted. Her symptoms did not reoccur after use of another type of root canal sealer.
서울에서 설문지와 메타콜린 기관지유발시험을 이용한 성인 천식 유병률
김상훈(Sang Hoon Kim),김윤근(Yoon Keun Kim),조상헌(Sang Heon Cho),민경업(Kyung Up Min),김유영(You Young Kim),이재영(Jae Young Lee),손성욱(Sung Wook Son),장윤석(Yoon Suk Chang),정재원(Jae Won Jung) 대한천식알레르기학회 2001 천식 및 알레르기 Vol.21 No.4
Background:There have been no reports concerning asthma prevalence in the Korean adult population using objective parameters such as methacholine bronchial provocation tests. Objective: The purpose of this study was to evaluate the prevalence of asthma using an objec- tive parameter, and the atopy rate in an adult population living in Seoul. Method: A total of 718 subjects (aged from 16 to 70 years) were enrolled in this study. They responded to a modified ATS respiratory questionnaire and underwent methacholine bronchial challenge and skin prick testing to common aeroallergens. Results: The prevalence of current asthma, based on the questionnaire and bronchial challenge, was 3.4%. The prevalences of current asthma and bronchial hyperresponsiveness were higher in subjects over 50 years of age than in those under 50 years of age. The atopy rate, based on the skin prick testing, was 26.9%, and common sensitizing allergens in decreasing frequency were Dermatophagoides farinae (15.5%), D. pteronyssinus (14.2%), Tyrophagus putrescentiae (5.9%), cockroach (5.0%) and Tetranychus urticae (4.9%). Conclusion: The prevalence of current asthma and the rate of atopy in an urban adult population were 3.4% and 26.9%, respectively. (J Asthma Allergy Clin Immunol 21: 618-27, 2001)