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키토산 연고기재를 통한 수용성 Riboflavin의 Rat 피부투과
오은하 ( Eun Ha Oh ),이길홍 ( Kil Hong Lee ),신현진 ( Hyun Jin Shin ),김운겸 ( Woon Geum Kim ),조성관 ( Seong Kwan Cho ) 한국키틴키토산학회 2008 한국키틴키토산학회지 Vol.13 No.1
Among these application fields, Drug delivery system(DDS) is often used as the method of drug dosage into the epidermic skin. We investigated characters of transdermal therapeutic system(TTS) and the skin permeability of that with applying DDS. Chitosan was selected as material of TTS. We investigated the permeation of chitosan ointment containing drug in rat skin using horizontal membrane cell model. Permeation properties of materials were investigated for water-soluble drug such as riboflavin in vitro. We used glycerin, PEG 600 and oleic acid as enhancers. Since dermis has more content water(hydration) than the stratum corneum, skin permeation rate at steady state was highly influenced when glycerin was used in water-soluble drug. The permeation rate of content enhancer and drug was found to be faster than that of content water-soluble drug only. These results showed that skin permeation rate of drug across the composite was mainly dependent on the property of ointment base and drug. Proper selection of the polymeric materials which resemble and enhance properties of the delivering drug was found to be important in controlling the skin permeation rate.