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- 저자 : 김시현 ( Cy Hyun Kim ) (검색결과 1 건)
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당뇨병성 신증쥐에서 retinoid와 PPAR-γ 촉진제 병합투여에 관한 연구
한상엽 ( Sang Youb Han ),김시현 ( Cy Hyun Kim ),한금현 ( Kum Hyun Han ),차대룡 ( Dae Ryong Cha ),김한성 ( Han Seong Kim ) 대한신장학회 2007 Kidney Research and Clinical Practice Vol.26 No.5
Purpose : An inflammatory mechanism has been suggested to contribute to the progression of diabetic nophropathy. Both retinoid and PPAR-7 agonist, known anti-inflammatory agents, have been reported to be beneficial in diabetic nephropathy. Because they form heterodimer for transcription within the nucleus, we investigated the effect of a combination treatment with them in streptozotocin (STZ)-induced diabetic rats. Methods: STZ-induced diabetic rats were treated with retinoid and PPAR- r agonist. The effects were determined by measuring urinary monocyte chemoattractant peptide (MCP)-i, proteinuria, and intrarenal ED-1 expression. Results Blood glucose concentration was higher in diabetic rats than in control rats. Retinoid and PPAR- r agonist did not affect blood glucose concentration. Urinary protein excretion (8.6 I 0.69 vs. 22.1 mg/mgCr, p<0.0l) and urinary MCP-1 (19.8z3.4 vs. 61.5±6.1 pg/mgCr, p`cO.Ol) were significantly higher in diabetic rats at four weeks after the induction of diabetes compared with controls. Proteinuria in the group with retinoic acid (16.9 1.4, mg/mgCr, pcz0.05) and PPAR-7 agonist (14.6 `1.5 mg/mgCr, pc0.05) were decreased. Retinoic acid (42.2±2.7 pglmgCr, p<O.05) and PPAR- agonist (40.5 `4.2pg/mgCr, pc0.05) significantly suppressed MCP-1 level in diabetic rats. However, combination treatment ment was not effective to proteinuria and urinary MCP-1 concentration. Urinary protein excretion was significantly correlated with MCP-1 (r0.9, p`c0.0i). Immunohistochemistry revealed a significant increase in staining for ED-i protein in the diabetic kidneys. Both retinoid and PPAR-γagonist significantly suppressed intrarenal ED-i synthesis. However combination treatment didnt show any additional beneficial effects. Conclusion: Both retinoic acid and PPAR-γagonist suppressed preteinuria and inflammatory changes in diabetic rats. However, there were no additional effects of the combination treatment present. Further ressrch is needed to determine the effect of the combination treatment on diabetic nephropathy.
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