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흰쥐의 척수손상 모델에 제대혈유래 중간엽줄기세포의 이식부위에 대한 행동학적 움직임에 관한 연구
박상인 ( Sang In Park ),김성묵 ( Seong Muk Kim ),임정연 ( Jung Yeon Lim ),정창현 ( Chang Hyun Jeong ),전진애 ( Jin Ae Jun ),전신수 ( Sin Soo Jeun ) 한국조직공학과 재생의학회 2006 조직공학과 재생의학 Vol.3 No.2
Multipotential mesenchyman stem cells (MSCs) can differentiate into the neural cells in vitro and they have been shown to promote neuronal survival and functional recovery after implantation into various neurological disease models such as cerebral infarction, brain trauma, spinal cord injury and Parkinson disease. In this study, we examined the effect of human umbilical cord blood-derived MSCs (hUCB-MSCs) on spinal cord injury (SCI) model saccording to the transplantation site through functional recovery test, cavity volume and migration to injury site. The spinal cord was injured by contusion using a weight-drop at the level of T9. The seven days after injury, the hUCB-MSCs (5 × 105 cells/?l) labeled with PKH26 were transplanted into rostral, caudal, epicenter sites of SCI. The results were: (1) a behavioral test (BBB score) showed a significant functional improvement in groups that had transplanted MSCs into rostral site as compared to transplanted group into caudal or epicenter site, (2) the cavity volume was the smallest in MSCs transplanted groups into rostral site, and (3) PKH26-labeled cells observed around the injury site were a greater in MSCs transplanted group into rostral site than other groups. Taken together, rostral site would be a valuable when performing stem cell transplantation therapy for treating SCI.
뇌졸중 쥐 모델에서 인간 제대혈 유래 중간엽줄기세포의 치료 효과 연구
정창현 ( Chang Hyun Jeong ),임정연 ( Jung Yeon Lim ),박상인 ( Sang In Park ),김성묵 ( Seong Muk Kim ),전진애 ( Jin Ae Jun ),오원일 ( Won Il Oh ),이재권 ( Jae Kwon Lee ),전신수 ( Shin Soo Jeun ) 한국조직공학과 재생의학회 2006 조직공학과 재생의학 Vol.3 No.4
Mesenchymal stem cells(MSCs) have the ability to differentiate into multiple cell types. It has been reported that MSCs ameliorate functional deficits after transplantation into various neurologic disease models. In this study, to demonstrate the effect of human umbilical cord blood-derived MSCs(hUCB-MSCs) on stroke models, we transplanted the PKH-26 labeled hUCB-MSCs into the contralateral region of injured rat brain at 7 days after injury, and then examined the behavioral test, migration ability of transplanted hUCB-MSCs to injury site, and differentiation potentiality of transplanted hUCB-MSCs into neural cells. The results were: (1) a behavioral test(adhesive- removal and rotarod test) showed a significant improvement in the MSCs transplanted group as compared to the PBS injected group, (2) PKH-26 labeled MSCs were detected in the boundary zone of injured site at 4 weeks after transplantation, and (3) a few of transplanted MSCs exhibited a labeling for mature neural linage markers NeuN and GFAP. We suggest that hUCB-MSCs could be an effective cell source for treating ischemic brain injury.