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국산홍화자(國産紅花子) 및 국산홍화자(國産紅花子)와 estradiol 병용투여가 난소적출로 유발된 흰쥐의 골다공증에 미치는 영향
김종헌,김미려,변부형,박지하,김종대,이은숙,서부일,Kim, Jong-Hun,Kim, Mi-Ryo,Byun, Bu-Hyung,Park, Ji-Ha,Kim, Jong-Dae,Lee, Eun-Sook,Seo, Bu-Il 대한한의학방제학회 2001 大韓韓醫學方劑學會誌 Vol.9 No.1
Objective: The present study has been undertaken to investigate the effects of Korean Carthami Semen and Estradiol-Carthami Semen co-treatment on osteoporosis in ovariectomized rats. Method: In this experiment, the rats were ovariectomized. Rats were administered 3 kinds of medicine, Korean Carthami Semen, Estradiol, and Estradiol-Carthami Semen, which were taken orally. The levels of bone mineral density, osteocalcin, estradiol, ALP, phosphorus, calcium in serum, deoxypyridinoline in urine, calcium, phosphorus, ash weight of bone, body weight and uterus weight were measured. Results: These experimetal results, it appears that the only Carthami Semen have more less efficacy on osteoporosis but $E_2$-Carthami Semen co-treated group showed more effective on osteoporosis. Conclusions: Further west-east medicine combination study should be conducted to illustrate in depth the curing osteoporosis.