자궁경편평상피암세포의 핵용적에 대하여

김명자(MJ Kim) 대한산부인과학회 1969 Obstetrics & Gynecology Science Vol.12 No.5

The nuclear volumes of the spinal, transition,and spindle cells, in squamous cell carcinoma of the cervix, srtained with hematoxylin and eosin were measured and compard with each other. The nuclear volumea were calulated by Matthias, Lange and Hertl`s formula,after the longest and shortest diameters of the cells were measured with "Zeiss Winkel`s Zeichnen Apparatus" attached to the microscope. The results obtained are as follows: 1) Mean volume of spinal cells.------------------------------------------------310.30u3 2) Mean volume of transitional cells.------------------------------------------159.27u3 3) Mean volume of spindle cell.------------------------------------------------51.62u3

10회의 정상분만을 경험한 Rh 부적합부부

김명자(MJ Kim),송태섭(TS Song),김홍택(HT Kim) 대한산부인과학회 1972 Obstetrics & Gynecology Science Vol.15 No.11

10회의 정상분만을 경험한 Rh 부적합부부의 증례를 보고하는 바이다. The Rh-negative blood type is extermely rare among Koreans. Its occurrence is 0.15% according to Dr. Won. An Rh-negative woman(50 years of age, para:10-0-1-7, pheno-and geno-type of Rh-subgroups: CcdEe, Cde/cde, respectively, titration of anti-D: negative, gynecological diagnosis: carcinoma in situ of the cervix) is presented with a brief case history and a revies of literatures on it.

X선 조사가 사람 백혈구 염색체에 미치는 영향에 관한 연구

김명자(MJ Kim) 대한산부인과학회 1974 Obstetrics & Gynecology Science Vol.17 No.1

단기간 X선조사가 사람 백혈구염색체에 미치는 영향을 비교 관찰하기 위하여 X선치료를 받 은 자와 10년 이상의 X선 조업의 경력을 가진 자를 대상으로 하여 X선으로 인한 백혈구 혐 색체의 수적 및 형태학적 변화를 탐구하였다. 백혈구의 배양은 Moorhead 등의 변법에 의하였으며 이상염색체의 분류는 Millard 법에 따 라 시행한 결과 다음과 같은 결론을 얻었다. 1) 정상대조례와 유암환자의 X선대조례에서 염색체의 이수성세포의 출현빈도는 hypodiploid 세포가 hyperdiploid 보다 우세하였다. 형태학적 변이로는 염색분체형의 것만이 발견되어 정 상대조례에서는 0.57% 유암환자의 X선대조례에서는 1.16%이었다. 그외의 염색체형의 변이 는 관찰되지 않았다. 2) 유암환자의 X선대조례에서 선량이 약 2,000 rad에 도달하였을 때의 염색체의 이수성세포 는 각례에서 12.6%와 7.9%로 출현하여 평균 11.2%가 되었으며, 염색분체형의 변이는 0.90% 로 증가를 보이지 않은 반면 염색체형변이는 안정형으로 1.80%, 불안정형으로 3.60%로 현 저한 증가를 나타내었다. 3) 약 4,000 rad의 선량이 대조완료된지 24시간 후에서는 염색체의 이수성세포의 출현빈도 는 각각 14.3%와 13.5%로 평균 13.8%의 증가된 빈도를 나타내고, 이때도 hypodiploid 세포 가 많았다. 한편 염색분체형변이는 0.94%로 변화가 없었으나, 염색체형변이는 계속 증가되 어 안정형이 10.37%이고 불안정형이 16.98%에 도달하였다. 4) 장기 X선조업자에 있어서는 이수성 세포의 빈도가 4.2%로 정상대조례군과 차이가 없었 으며, 염색분체형변이는 평균 1.10%이었다. 염색체형변이에 있어서는 안정과 불안정형이 각 각 2.56%와 0.73%로 약간의 증가를 보이고 안정형에서 더욱 명확하였다. 5) 유암환자 X선대조례와 X선조업자례에서 나타난 hypodiploid와 hyperdiploid 세포들을 분 류하여 본 결과 hypodiploid 세포들은 전군(A∼G)에 분포되어 있었고 특히 C군에 많았으며, hyperdiploid 세포들은 주로 이상염색체로 구성되어 있었다. 6) 유암환자례에 있어서 형태학적 변이는 불안정형이 많았고, 그 출현빈도는 이중착사점염 색체, 환상염색체, 단편의 순위었으며, 안정형에서는 결실이 많았다. 반면 X선조업자례에서 는 안정형이 월등히 많이 발생됨을 볼 수 있었다. An attempt has been made to observe chromosomal aberrations in the human leucocytes induced by X-ray irradiation. Two mastectomized cases of breast cancer, four X-ray technicians, and two healthy men for a control were for a control were arbitrarily chosen for the purpose of studying radiation effects on peripheral leucocytes in terms of the number and morphology of their chromosomes. The chromosomes in the two mastectomized cases were observed before, during, and 24 hours after the postoperative X-ray irradiation with a daily dose of 200 rad for the period of 19 to 22 days, respectively. Four X-ray technicians chosen are those who have been engaged themselves in X-ray manipulation for more than ten years. The chromosomes preparations were made with a modified technique of Moorhead et al. The results obtained are as follows : 1) The number of chromosomes in the control cases and the pre-irradiated mastectomized patients of breast cancer showed aneuploidy of 4.9% and 5.0%, respectively, with predominently hypoploid cells. The occurrence of the abnormal chromosomes showing only chromatid aberration was 0.57% and 1.16% in each group. 2) The number of chromosomes of two X-ray irradiated cases with 1,725 rad and 1,600 rad for each case showed an increased aneuploidy of 11.2%. Although the occurrence of the abnormal chromosomes was prominent, the chromatid aberration showed only 0.90%. The percentage of the cells containing stable type of abnormal chromosomes was 1.80% and that of unstable type 3.60%. 3) Changes in the number of chromosome and the occurrence of abnormal chromosomes in the post-irradiated cases with the total doses of 3,600 rad and 4,400 rad for each case showed 13.8% in aneuploidy, and 0.94% in chromatid aberration (10.37% in stable type and 16.98% in stable type). 4) The number of the abnormal chromosomes of the X-ray technicians showed normal rate of aneuploidy of 4.2% and an increased chromatid aberration of 1.10%. The number of cells with the chromosomes of stable and unstable types showed a considerable increase of 2.56% and 0.73%, respectively. 5) The number of missing chromosomes in hypodiploid cells in the irradiated cases was more prominintly increased than that of X-ray technicians. 6) The ratio of hypodiploid to hyperdiploid cells in control group, X-ray treated cases, and X-ray technicians showed no significant difference. The dominant types of chromosomal aberrations in both X-ray treated cases and X-ray technicians were `deletion` for stable cells and `dicentrics` for unstable cells.

완전내장전착증의 1례

김홍택(HT Kim),이현식(HS Lee),김명자(MJ Kim),장윤석(YS Chang) 대한산부인과학회 1969 Obstetrics & Gynecology Science Vol.12 No.4

Situs inversus per se is a relatively eaew and harmless condition. The reported incidences of this abnormality vary greatly from 1:2,000 to 1:40,000. No more than 25 cases have been reported in Korea, since the first case was described by Ho Sup Shim in 1923. Because of great compatibility of this condition with apparently normal life, many individuals are doomed to be undiagnosed or overlooked even in such instances a being complicated by other conditions. One case of a 34-year-old Korea housewife was presented. She had been left undiagnosed until her third pregnancy resulted in the repeat cesarean section.

지상아를 동반한 쌍태임신

조석신(SS Cho),김명자(MJ Kim),김선원(SO Gim),김성심(SS Kim) 대한산부인과학회 1968 Obstetrics & Gynecology Science Vol.11 No.8

Fetus papyraceus is a rare complication of multiple pregnancy. Recently, we had a chance to study a case of fetus papyraceus in monochorial twin pregnancy at the Dept. of Obstetrics and Gynecology, Seoul National University Hospital. A Case of fetus papyraceus is presented with brief review of the literatures.

이중 유출로를 가진 우심실

정좌구(JK Chung),지제근(JG Chi),김선원(SO Gim),조석신(SS Cho),이상국(SK Lee),김명자(MJ Kim) 대한산부인과학회 1968 Obstetrics & Gynecology Science Vol.11 No.1

Double outlet right ventricle is a rare congenital anomaly of the heart. The malformation represents a furthter rotation of the aorta than that which occurs in the tetralogy of Fallot. Witham in 1957 reported the clinical and pathological findings of four cases of this anomaly and named the condition to be double outlet right ventricle. He discussed this anomaly as a partial transposition of great vessels. Recently we had a chance to examine a stillborn infant who was born from a 36 years old multiparous woman of preeclamptic condition. At autopsy the aorta is so far dextroposed that it arises entirely from the right ventricle. The pulmonary artery occupies its normal position and lies anterior to the aorta. (Vide figures). Aorta is not hypoplastic. A relatively large ventricular septal defect was found in the memtraneous portion of ventricular septum. Authors presume this case is the first autopsy-proven case of double outlet right ventircle published in Korean literature.