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      • KCI등재

        난소홀몬이 자궁내 포도당 및 당원질대사에 미치는 영향

        김득구(DK Kim) 대한산부인과학회 1965 Obstetrics & Gynecology Science Vol.8 No.10

        Sixty of ovariectomized albino rats were divided into 3 groups; first group for control, second group for estrogen stimulated group and third group for progesterone stimulated group. In each group, uterine tissues were excised by sacrificing at 1 or 2 week after ovariectomy, and homogenated by glass homogenizer with C14-glucose incubation medium in which were added universally labeled C14-glucose and non radioactive glucose into Krebs-Ringer phosphate buffer so as to maintatain the glucose concentration of 200 mg%. About 5 ug of estradiol was injected subcutaneously in the second group and 10 mg of progesterone in the third group at 10 hours before sacrificing the ovariectomized rats of respective group. Tissue homogenate obtained from each group was inubated for a period of 4 hours by Dubnoff metabolic shaking incubator. At the end of experiment, concentrations of glucose and glycogen and radioactivities of glycogens were analyzed from homogenate samples and total CO2 production rates and radioactivities of CO2 from the CO2 samples which were trapped in the center well of reaction flask in the each run of each group. From the data obtained in each group, the effect of stimulation of ovarian hormone on the oxidative metabolism of C14-glucose and turnover rate of glycogen of uterine tissues were oberved as follow. 1) Glucos consumption rates were mean of 3.10uM/hr/gm in the first group, 3.34uM/hr/gm in the second group and 4.78 uM/hr/gm in the third group. There were little difference in glucose consumption rates between control and estrogen stimulated groups, but glucose consmption rate in progesterone stimulated group increased about 54% of control value. 2) Total CO2 production rates were mean of 3.5 uM/hr/gm, in the control group, 14.5 uM/hr/gm in the second group and 16.2 uM/hr/gm in the trird group. There are remarkable increase in oxidative metabolism of uterus by stimulation of ovarian hormone. Relative specific activities (RSA), which were the fractions of CO2 derived from C14-glucose to total CO2 production rates, were calculated average of 7.0% in the first group. 27.0% in the second group and 20.5% in the third group. Co2 production rate from medium C14-glucose showed average of 0.25Um/hr/gm which is equivalent only 1.3%(RGDco2) of glucose consumption rate in the control. Therefore, contribution of glucose on the oxidative metabolism is negligible in the control tissue. However, CO2 production rates from glucose in the ovarian hormone stimulated groups, were remarkably increased showing average of 0.65uM/hr/gm which value is about 16 times of control value in the second group and 0.55uM/hr/gm which is about 13.8 times of control in the third group. RGDco2, which are fractions of glucose consumed into respiratory CO2 to total glucose consumption rates, were mean of 19.5% in the second group and 11.6% in the third group. From the above data, it seems that ovarian hormone stimulate the oxidation of glucose in the uterine tissue. 3) Concentrations of glycogen were mean of 0.49mg/gm in the first group, 1.44mg/gm in the second group and 0.85 mg/gm in the third group. There is prominent increase in the estrogen stimulated group. In each group, concentration of glycogen were maintained relatively constant value during experimental period and difference of SA of medium C14-glucose and SA of glycogen were decreased exponentially with time, showing straight line on the semilogarhythmic paper. Therefore, turnover of glycogen in the uterine tissue is followed by first order kinetic reaction. Turnover rates calculated by first order kinetic equation showed 1.72%/hr in the control, 12.65%/hr in the second group and 9.77%/hr in the third group. Glycogen turnover increased prominently by ovarian hormone.

      • KCI등재

        보존혈액의 혈청응집소 역가의 변동에 대하여

        김득구(DK Kim) 대한산부인과학회 1961 Obstetrics & Gynecology Science Vol.4 No.3

        1. 저자는 계단희석법에 의하여 19예의 보존혈액 혈청내응집소력가가 채혈후 4주일에는 저하되는 경향을 볼 수 있었다. 2. 배수희석법에 의하여서는 채혈후 4주까지는 변동이 없는 것으로 보아서 그 역가에 큰 변동은 없는 것이며 계단희석으로 미약한 저하를 초래함을 볼 수 있었다. 3. 보존혈액의 혈구피응집력가도 예비실험에서 시일이 경과함에 따라서 변동됨을 확인하였다. 4. 보존혈액의 형태학적 및 화학적변화는 채혈후 1주일에는 변동이 있는 것으로 알려졌으나 응집소력가에 있어서는 유효기간내에서는 별 변동이 없다. 5. 실온에서 혈액을 보존하여 역가변동을 관찰하려고 기도하였으나 수일내로 보존혈액의 부패 용혈 등의 변화를 일으켜 실험이 불가능하였다. The titer of agglutinins vary with individuals and also depends upon the varieties of test, temperature and duration before the test is conducted. An attempt was made to clearify the variations in serum agglutinin titer in the stored blood. The results obtained are as follows: The sera used in this study were diluted by the double and gradual dilution method to observe the variation of anti-A type and anti-B type agglutinin titers in the stored blood. The titer was first determined on the day the blood was taken, and thereafter, four consecutive determinations were made for the same sample at the interval of one week. In the light of individual differences in the agglutinogen titer, two and same persons having blood type A and type B were selected and their erythrocytes were used throughout the tests. Nineteen stored blood samples were tested, and a little changes in general, were noticed up to 3 weeks. Only 2 cases of type A showed a slight diminution of titer. Slight diminution of titers were noticed in the majority of cases after the 4th week. Therefore, the tendency of diminution of agglutinin titers in the stored blood becomes more remarkable as the time of storage goes on. After the 5th week of storage of the blood, the results of the test are hardly to be interpreted due mainly to hemolysis.

      • KCI등재

        자궁내번증 1예

        김영철(YC Kim),김득구(DK Kim),장윤석(YS Chang),신면우(MW Shin) 대한산부인과학회 1963 Obstetrics & Gynecology Science Vol.6 No.6

        A case of puerperal inversion of the uterus was presented which was caused by mismanagement in the 3rd stage of labor. And a brief review of literature on the puerperal inversion of the uterus was made.

      • KCI등재

        무뇌아의 2예

        박혁석(HS Pak),김득구(DK Kim),손종수(CS Son),정호성(HS Chung) 대한산부인과학회 1965 Obstetrics & Gynecology Science Vol.8 No.10

        One case of anencephalus without any external abnormalities associated with polyhydramnios, and another case of anencephalus associated with no pituitary gland and atrophied adrenal glands which were observed at Dept. of Ob. & Gyn. of Seoul Sanitarium & Hospital. are presented. And a brief review on anencephalus is presented.

      • KCI등재

        거대생존아만출을 포함한 복강임신의 2증예

        신면우(MW Shin),김득구(DK Kim),김영철(YC Kim),박재우(JU Park) 대한산부인과학회 1965 Obstetrics & Gynecology Science Vol.8 No.12

        Two cases of abdominal pregnancy are presented. Which we experienced in Nov. 1962, and Feb. 1963. It was uncertain that the 1st case was primary or secondary abdominal pregnancy or ovarian pregnancy. The 2nd one was a case of secondary abdominal pregnancy which was produced by perforation of uterine wall and evacuation of the conceptus into peritoneal cavity during D&C. It had been performed to interrupt the pregnancy at the 2nd month. The live female baby1, weighing 4.7kg was delivered abdominally. A brief review of the literature of abdominal prepnancy was done.

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