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판토프라졸이 난소 적출한 ICR 생쥐의 골교체에 미치는 영향
임은혜 ( Eun Hye Lim ),김기현 ( Key Hyeon Kim ),이범재 ( Beom Jae Lee ),주문경 ( Moon Kyung Joo ),고진성 ( Jin Sung Koh ),이준영 ( Joon Young Lee ),임상아 ( Sang Ah Lim ),김지훈 ( Ji Hoon Kim ),연종은 ( Jong Eun Yeon ),박종재 ( Jo 대한내과학회 2011 대한내과학회지 Vol.80 No.1
Background/Aims: Long-term exposure to proton pump inhibitors is associated with osteoporosis-related fractures; however, the mechanism is unknown. The purpose of this study was to evaluate the effect of pantoprazole on osteoporosis and bone turnover in ovariectomized ICR mice fed a calcium-free diet. Methods: Ovariectomized female ICR mice were divided into a pantoprazole group (n=10) and a control group (n=10). The mice in the pantoprazole group were given an intraperitoneal injection of pantoprazole at 20 mg/kg twice daily. After 4 weeks, the mice were humanely euthanized, and bone mineral density (BMD) and dry tibia weight were measured. Serum osteocalcin and CTX-1 levels were measured by enzyme-linked immunosorbent assay. The mRNA expression levels of cytokines that stimulate osteoclast differentiation were determined using RT-PCR. Serum calcium, phosphorus, and alkaline phosphatase (ALP) levels were also analyzed. Results: Serum osteocalcin concentration was significantly lower in the pantoprazole group compared with the control group (p=0.023). There was no difference in BMD, dry tibia weight, or serum ALP, calcium, phosphorus, or CTX-1 between the two groups. The expression of interleukin (IL)-1β was lower in the pantoprazole group compared with the control group, but not significantly lower (p=0.058). The levels of tumor necrosis factor-α and IL-6 did not differ between the two groups. Conclusions: Pantoprazole, a proton pump inhibitor, decreased serum osteocalcin and suppressed IL-1β expression, suggesting that pantoprazole affects bone formation and resorption in ovariectomized ICR mice. Further studies using larger sample sizes are needed. (Korean J Med 2011;80:56-62)
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