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RISS 인기검색어
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- 저자 : 김건주 ( Geon Ju Kim ) (검색결과 1 건)
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경증 급성 하기도 감염을 앓는 소아에서의 혈청 사이토카인과 임상 양상의 상관관계
김건주 ( Geon Ju Kim ),박유미 ( Yu Mi Park ),원설 ( Sul Mui Won ),최승준 ( Seung Jun Choi ),김환수 ( Hwan Soo Kim ),전윤홍 ( Yoon Hong Chun ),윤종서 ( Jong-seo Yoon ),김현희 ( Hyun Hee Kim ),김진택 ( Jin Tack Kim ) 대한천식알레르기학회 2017 Allergy Asthma & Respiratory Disease Vol.5 No.2
Purpose: Acute lower respiratory infection (ALRI), which is frequently encountered in pediatric patients, is the leading cause of hos pitalization. We aimed to identify particular cytokines that correlated with ALRI clinical characteristics. We also aimed to identify any differences in cytokines between respiratory syncytial virus (RSV)-related ALRI and non-RSV-related ALRI. Methods: Cytokine levels were measured in the sera sampled from 103 pediatric patients diagnosed with ALRI and admitted to Seoul St. Mary`s Hospital between May 2012 and April 2013. The correlations between cytokine levels and the length of hospitaliza tion, the number of days with fever, body temperature, pulse rate, respiration rate, oxygen saturation upon admission, and duration of oxygen supplementation were analyzed. Results: In children with ALRI, the level of interleukin (IL)-6, granulocyte-colony stimulating factor (G-CSF), and IL-10 were correlated with a higher body temperature on admission. In addition, the IL-8 level was correlated with pulse rate and respiration rate, and IL-1β level was related with oxygen saturation on admission. In children with RSV-related ALRI, the IL-6 was correlated the with dura tion of fever, and the IL-1β, IL-2, and IL-8 levels were related to pulse rate and respiration rate. In addition, the increase in interferon-gamma-inducible protein-10 (IP-10) level was correlated with a higher body temperature on admission and a longer duration of hospitalization in children with RSV-related ALRI. Conclusion: In children with ALRI, the levels of IL-6, IL-8, IL-1β, G-CSF, and IP-10 were correlated with its clinical features. In children with RSV-related ALRI, the IL-1β, IL-2, IL-6, IL-8, and IP-10 level was correlated with the severity of the disease. (Allergy Asthma Respir Dis 2017:5:99-104)
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