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사역산의 항우울효과 및 뇌내 monoamine에 미치는 영향
신화석 ( Hwa Suk Shin ),권영모 ( Young Mo Kweon ),박선동 ( Sun Dong Park ) 대한본초학회 2004 大韓本草學會誌 Vol.19 No.2
N/A Objective: The purpose of this study was to reseach antidepressant effect and influence on monoamines of Sayuksan which is thought to have some antidepressant according to oriental medicine theory. Methods: We used forced swimming test(FST) to know antidepressant effect of Sayuksan and HPLC to check the influence on monoamines and their metabolites(norepinephrine, dopamine, DOPAC, HVA, serotonin, 5-HIAA) of Sayuksan after divided into cerebral cortex, striatum, hypothalamus and hippocampus. Results: In the study of antidepressant effect by forced swimming test(FST) method, Sayuksan had a significant antidepressant effect. In the study of influence on monoamines by HPLC. Sayuksan mainly increased dopamine and serotonin signigficantly among monoamines in 4 parts of rat`s brain above-mentioned. Conclusion: These results suggest that Sayuksan has antidepressant effect that may be related with the increase of dopamine and serotonin as its mechanism.