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21일간 methomyl에 노출한 미꾸리의 생물지표 및 내분비계 영향
한선영(Sun-Young Han),김자현(Ja-Hyun Kim),권가영(Ga-Young Gwon),염동혁(Dong-Hyuk Yeom) 한국농약과학회 2012 농약과학회지 Vol.16 No.1
To evaluate the effect of endocrine disruption chemicals (EDCs) to aquatic organisms, muddy loach (Misgurnus anguillicaudatus) was exposed to low concentration methomyl for 21 days in order to identify the effect of biomarkers and endocrine. Vitellogenin (VTG) in blood plasma, which used widely as validated biomarker for endocrine disruption, was significantly greater in male fish exposed to 0.4 ㎎/ℓL and 2 ㎎/ℓ methomyl, and in female fish exposed to 0.08 ㎎/ℓ, 0.4 ㎎/ℓ, and 2 ㎎/ℓ methomyl for 21 days (p<0.05). This results suggest that methomyl have probability of endocrine disruption to organism on aquatic system. While inhibition of Acetylcholinesterase (AChE) activity and increase of DNA damage in comet assay were verified by fish exposed to methomyl, change of ethoxyresorufin-O-deethylase (EROD) activity was not occurred, comparing the control group (p<0.05). Indicators at the level of organism such as condition factor (CF), hepato-somatic index (HSI), and gonado-somatic index (GSI) were not influenced by exposure of methomyl. In conclusion, these results showed the possibility of methomyl in regard to not only endocrine disruption but also impacts on biochemical biomarkers to aquatic organisms.