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3차원 해면골 구조에서 뼈세포의 유체전단응력 및 물리적 압축력에 대한 생체 외 반응 연구
김병관 ( Byung Gwan Kim ),곽지현 ( Ji Hyun Kwag ),김한성 ( Han Sung Kim ),김경환 ( Kyung Hwan Kim ),김지현 ( Chi Hyun Kim ) 한국조직공학·재생의학회 2009 조직공학과 재생의학 Vol.6 No.4
Mechanical loading is a critical factor that regulate functional bone adaptation and trabecular bone architecture is dependent on the mechanical environment within bone tissue. The aim of this study is to investigate the bone cell response to mechanical loading in a 3D trabecular bone environment using two different bone cell loading mechanism. We established a 3D trabecular bone explant model and applied either oscillatory fluid flow induced shear stress or cyclic compressive strain. Our results indicate that fluid shear stress increases alkaline phosphatase activity as well as mRNA levels of collagen type I and core binding factor 1. Mechanical compressive strain also increases alkaline phosphatase activity and collagen type I mRNA but to a lesser degree compared to fluid shear stress. These results suggest that fluid shear stress may be a more potent stimulus than cyclic compressive strain in inducing bone formation in 3D trabecular bone structure.