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Type 2 DM 환자에서 인슐린 또는 경구혈당강하제등의 치료에 의한 인슐린 내지환와 Dagradation 장애의 회복
박원근(Won Kun Park),고완(Wang Ko),최웅환(Woong Hwan Choi),한인권(In Kwon Han),김선우(Sun Woo Kim),정운원(Woon Won Jeng),문인걸(In Gul Moon) 대한내과학회 1988 대한내과학회지 Vol.35 No.4
N/A The internalization of I-insulin in human erythrocytes was studied using an acid extraction technique (pH 5.7, PBS) from 7 patients with type 11 diabetes mellitus (DM) and 14 normal subjects before and after glucose control. Insulin degradation products from 4 patients with type 11 DM and 14 normal subjects in the same period were assayed using HPLC with Sephadex G-50 column and a radioisotope detector. The maximal rates of insulin internalization (Incubation time: 4 hours, at 37°C) which were decreased before glucose control (50.25±6.99%vs 80.23±7.73%), returned toward normal levels after glucose control (89.5±5.45%). The maximal degradation products of insulin (incubation time: 4 hours, at 37°C) which were decreased before glucose control (62.25±10.50vs 87.75±6.66%), returned toward normal levels after glucose control (91.4±7.60%). These results suggest that in type 11 DM, the decreased rate of insulin internalization and degradation may be one of the contributory factors in the pathogenesis of postbinding resistance, which is reversible with insulin or sulfonylurea treatment.