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참외추출물이 스코폴라민 유도 기억상실 흰쥐의 인지능 회복에 미치는 효과
박상신(Sang-Shin Park),박나오미(Naomi Park),강주억(Ju-Uk Kang),신석철(Suk-Chul Shin),이동웅(Dong-Ung Lee) 한국생명과학회 2009 생명과학회지 Vol.19 No.5
The methanol extract of muskmelon (Cucumis melo) has been investigated for its cognition enhancing effects by evaluation of inhibitory activities on acetylcholinesterase, a degrading enzyme of acetylcholine, a brain neurotransmitter, and β-secretase, which forms the β-amyloid toxic protein from its precursor protein. A passive avoidance task, one of the animal model experiments for learning and memory, was also performed. As a result, the melon extract showed 15.8% and 35.3% inhibition on acetylcholinesterase and β-secretase, respectively, with a final concentration of 100 ㎎/ml. In the animal model test, melon extract significantly (p<0.05) lengthened the step-through latency time by 22.7% compared to the control group, suggesting that melon extract has, indeed, an effect on cognition enhancement.