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RISS 인기검색어
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- 저자 : 강계원 ( Moon K Song (검색결과 2 건)
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송문기,김유형,조철오,강계원 ( Moon K Song,You Young Kim,Cheol O Joe,Ke Won Kang ) 생화학분자생물학회 1990 BMB Reports Vol.23 No.4
The effects of prostaglandin El [PGE1], testosterone, 17β-estradiol and indomethacin on the zinc flux rate across the jejunal segements isolated from rats of each sex were determined using the Ussing chamber technique. Addition of PGE1 [5.0 μM] to the segment bathing medium significantly stimulated the zinc flux rate from mucosa-to-serosa [J_(ms)] of the jejunal segements isolated from male rats and inhibited it in those from female rats. 17β-estradiol [10 nM] inhibited J_(ms) of jujunal segments isolated from male rats, but testosterone stimulated those from female rats. To confirm that testosterone stimulates and 17β-estradiol inhibits J_(ms), the effects of testosterone on the zinc flux rates of segments isolated from male rats and 17β-estradiol on those from female rats were determined. In those experiments, both testosterone and 17β-estradiol inhibited J_(ms) without affecting the zinc flux rate from serosa-to-mucosa [J_(sm)]. However, when rats were ovariectomized, both of these steroid hormones stimulated J_(ms). Interestingly neither PGE1 nor steroid sex hormones produced any effect on the J_(sm), although indomethacin stimulated the J_(sm) of segments from male rats. These results suggest that steroid sex hormones interact with PGs in influencing the intestinal zinc transport and that endogenous PGs and steroid sex hormones augment the effects of exogenous hormones and PGs.
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성별에 따른 아리키돈산에 의한 장관내 칼슘 흡수의 차이
송문기,David B . N . Lee,조철오,강계원 ( Moon K . Song,David B . N . Lee,Cheol O . Joe,Ke Won Kang ) 생화학분자생물학회 1992 BMB Reports Vol.25 No.2
Based on the finding arachidonic acid (AA) stimulates, and prostaglandin (PGE₂) inhibits calcium absorption in female rats in vivo, we examined whether or not arachidonic acid also stimulates calcium absorption in male rats in vivo as well as in vitro. When 1 ㎎ of AA was given to male rats two times via gastric intubation, 24 and 4 h before sacrifice, and 20 μCi of ^(45)Ca (10 μCi/㎎) 1 h before sacrifice, organ ^(45)Ca contents significantly decreased compared with control rats. When the same amount of AA and ^(45)Ca were given to female rats, organ ^(45)Ca contents significantly increased compared with control rats. When duodenal segments from the same experimental rat groups studied in vivo were mounted to Membrane Ion Transport Chambers to measure the net ^(45)Ca absorption rates in the male rats, there was no significant difference between the control rats and those treated with AA, while the net ^(45)Ca absorption rate was significantly higher for AA-treated female rats compared with control rats. In contrast, when 10 μM AA was added to the duodenal segment bathing medium in the Membrane Ion Transport Chamber experiments, the net ^(45)Ca absorption rate significantly decreased for male rats, but there was no discernible effect on female rats. These data demonstrate that the modulation of intestinal calcium absorption with AA added exogenously in vivo and in vitro is dependent on the sex of the animals. They also suggest that AA inhibits and AA metabolites other than PGE₂ stimulate the absorption of calcium, and these reactions are mediated by female sex hormones.
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