http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : 郭碩淳 (검색결과 3 건)
- 무료
- 기관 내 무료
- 유료
-
-
Cortisone이 肺胞貪細胞의 貪식機能에 미치는 影響에 關한 電子顯微鏡的 硏究
郭碩淳,洪錫宰 慶北大學校 醫科大學 1973 慶北醫大誌 Vol.14 No.2
著者는 正常白鼠 및 cortisone을 多量으로 投與한 白鼠에 墨汁을 血管內로 注入하고 肺胞食細胞들의 食 機能과 이들 細胞內小器官들의 變化 그리고 肺胞上皮細胞들의 變化를 病理組織學的 및 電子顯微鏡的으로 檢索하여 다음과 같은 結果를 얻었다. 1) 光學顯微鏡的으로는 cortisone을 多量으로 投與하여 綱內系를 塡塞한 實驗群에 있어서 肺組織의 炭粉沈着程度는 cortisone을 投與하지 않고 墨汁만 注入한 對照群에 있어서의 그것과 別差異가 없었으며 또 特記할만한 組織所見도 認定되지 않았다. 2) 電子顯微鏡的으로는 墨汁만 注入한 對照群에 있어서는 肺胞食細胞들은 活潑하게 炭粉을 食 하고 있었으나, cortisone을 投與하고 墨汁을 注入한 實驗群에 있어서는 炭粉이 極히 微弱한 程度로 탐식되었다. 그리고 對照群 및 實驗群에서 다같이 Ⅱ型 肺胞細胞의 osmiophilic inclusion body內의 多量의 炭粉이 沈着되어 있는 것이 特異하였다. 3) 上記 實驗成績으로 보아 墨汁을 血管內로 注入할 때에 肺에 있어서는 肺胞食細胞에 依한 食 보다도 더 많은 量의 炭粉이 Ⅱ型 肺胞細胞의 osmiophilic inclusion body內에 沈着되는 것으로 推定되며, 이 Ⅱ型 肺胞細胞內 炭粉沈着 現象은 cortisone의 影響을 別로 받지 않는 것으로 보인다. It is well known that the phagocytic action of the cells of the reticuloendothelial system play an imoprtant role in the immunological reaction and as a barrier against foreign bodies. It is also known that when the reticuloendothelial system is blockaded by cortisone, and adherence of the foreign bodies to the cell membranes of the phagocytes, an initial step of the phagocytic mechanism, and an absorption of the foreign bodies into the cytoplasms of the phagocytes are considerably disturbed. An investgation was undertaken to study this phagocitic activity of the alveolar macrophages and phagocytic functional aspect of the alveolar lining cells when sufficient doses of cortisone were dministered to experimental animals with a resultant reticulocendothelial system blockade, by light and electron microscopic examination. Eighteen albino rats, maintained on a stock diet, weighing about 200 gm average, were divided into 3 experimental groups. Group 1. congrol group. No intravenous injection of india ink given. a. 3 rats, untreated. b. 3 rats: a dose of 25 mg of cortisone acetate was given intramuscularly for 3 consecutive days. Group 2. 6 rats: A single dose of 2.0ml of 2% india ink in normal saline was given into the each tail veins. Group 3. 6 rats: A dose of 25mg of cortisone acetate was given intramucularly, once a day, for 3 consecutive days, Starting on the 4th day, a 2.0ml of 2% india ink in normal saline was administered once intravenously. The experimental rats were sacrificed each 15 minutes (3 rats) and 30 minutes (3 rats) after the treatment of india ink preparation from the group 2 and 3. The control group was sacrificed 24 hours after the last treatment of cortisone acetate. The the lung was extirpated and inspected for carvon pigmentation of the lung tissue, followed by both light and electron microscopic examinations. The results were as follows: 1. Light microscopic observations: In the experimental group of rats treated with 25mg doese of cortisone acetate with a resultant reticuloendothelial system blockade followed by an india ink injection (group 3), the degree of carbon particle deposition in the lung tissue was not diminshed over the group of rats treated with india ink only (group 2). 2. Electron Microscopic observations: In the control group of rats treated with india only (group 2), the alvolar macrophages were very active in engulfing the carbon paticles. In this group, a large quantity of carbon particles were found to be contained in phagosomes. However, in contrast to the control group, in the experimental group of rats treated with cortisone followed by an india ink injection (group 3), the phagocytic activity of the alveolar macrophages were poorly recognizable. Only a few pahgosomes bearing particles were found in the alveolar macrophages. Unexpectedly, a large quantity of carbon particles were accumulated in the osmiophilic inclusion bodies of the type Ⅱ alveolar cells in both the control and experimental groups. In conclusion then, as aslready described above, it was found that a considerably large quantity of carbon paricles were found in the osmiophilic inclusion bodies of the type Ⅱ alvolar cells than found in the alveolar macrophages when 2% india ink preparation was administered into the tail veins of both experimental and control group rats with or without cortisone pretratment. This massive accumulation of carbon particles in the osmiophilic inclusion bodies of the type Ⅱ alveolar cells does not appear to be affcted by cortisone administration with a resultant reticuloendothelial system blockade as is the case of alvelar macro phages which were singificantly inhibited of their phagccytic activity by cortisone treatment.
-
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
