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        韓國版 强迫尺度의 開發을 위한 豫備研究 — Modified Leyton Obsessional Inventory의 信賴度 및 妥當度 檢證 一

        元勝喜,姜秉祥 대한신경정신의학회 1995 신경정신의학 Vol.34 No.2

        As a self-reporting scale evaluating obsessional symptom, the M odified Leyton Obsessional Inventory is being used, which was developed by Cooper(1970) and modified and complem ented by Frankel et al(1986). To develop a Korean version o f obsessional scale, the author conducted a study on the reliability and validity through translation suitable to the Korean situation o f the Modified Leyton Obsessional Inventory. Thirty-four persons diagnosed as obsessive compulsive disorder(O CD ) by means of DSM-III-R were designated as the patient group and the control group consisted of 261 medical school students. The followings are the results of the study : the correlational coefficient of the total scores in the test-retest realiability was a relatively high of 0.85(p<0.001) ; in Cronbach’s a, both showed a high internal consistency with 0.9432 for the patient group and 0.9429 for the co ntrol; in the test of the reliability using the half-split method, the reliability conefficients by even and odd num bers showed high corelations o f 0.90 and 0.84 respectively - all these showed statistical significance. The patient group showed a significantly high score, in the com parison of the total scores between the patient group, 97.62± 35.75,and the control, 50.07± 24.71(p<0.05). In the distribution of frequencies in the total scores, 70 above accounted for 66.5% in the patient group and 19.5% in the control, a significant difference. In the relationship between scores and total scores of each scale of M.M.P.I.,both the patient and the control groups showed high corelation in ‘P t’ and ‘Sc’ items. Both groups also showed significantly high corelation in ‘Si’ • ‘M a’ • ‘P a’ • ‘H s’ items. As a reslut of factor analysis by the Varimax rotation, 9 factors were extracted. The 9 factors accounted for 64.0% of common variance explained and Factor I (obsession) takes up 32.5 %. In further studies, more variegated groups and patient groups should be taken as the subjects of study for a sustained study on fixing the cutoff level to differentiate OCD and standardization as against the norm al group of people. It is also recommended that studies on the validity together with various scales to diagnose more correct OCD should be carried out

      • KCI등재

        兩極性情動障碍와 人間組織適合性抗原

        崔泰珍,姜秉祥,鄭泰浩 대한신경정신의학회 1989 신경정신의학 Vol.28 No.4

        The author studied 51 Korean bipolar affective disorder patients who had been admitted to the Psychiatric departments of general hospitals and local psychiatric clinics located in Taegu from January, 1988 to August, 1988. The object of this study was to determine if HLA has genetic marker value to the susceptibility of the bipolar affective disorder. All of the 51 patients had a history of bipolar affective disorder over 2 years and the diagnosis was confirmed by Research Diagnostic Criteria(RDC). According to the Family History-RDC, the patients were subdivided into two family history groups. One group was with family history (14 patients) and the other was without family history (37 patients). The normal control group was composed of healthy medical school students (196 individuals for HLA-A, B, C and 205 individuals for HLA-DR). All the subjects were typed for HLA by Terasaki method at the Biomedical Research Laboratory, Kyungpook National University. Test results of the groups were compared by specific statistical method for HLA of Nam and Gart, and the significance was corrected by multiplying the number of test antigens (45) to the p-value. The results were as follows; 1) The bipolar affective disorder patient group had more HLA-B51 and HLA-DR8 (p〈0.0045) and HLA-C, (p<C0.045) than normal control groups, and less HLA-A33, HLA-C3 and HLA-C7 for p is less than 0.045. 2) There were no significant difference between patient groups with and without family history. 3) The susceptibility gene of bipolar affective disorder has association with HLA Loci which is located on the short arm of chromosome number 6. As a conclusion, HLA-B51, HLA-C1 and HLA-DR8 may have genetic marker values to the bipolar affective disorder in Korean.

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