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Inhibition of DNA Topoisomerases I and II of Compounds from Reynoutria japonica
( Kyoung Hwangbo ),( Ming Shan Zhang ),( Young Jin Kim ),( Jong Yeop Im ),( Chong Soon Lee ),( Mi Hee Woo ),( Yurngong Jahng ),( Hyun Wook Chang ),( Jong Keun Son ) 영남대학교 약품개발연구소 2013 영남대학교 약품개발연구소 연구업적집 Vol.23 No.0
Three anthraquinones (1, 2 and 4), three stilbenes (5, 6 and 7) and 3,5-dihydroxybenzyl alcohol (3) were isolated from Reynoutria japonica. Their structures were identified as emodin (1), emodin-8-O-β-D-glucoside (2), 3,5-dihydroxybenzyl alcohol (3), citreorosein (4), cis-resveratrol (5), trans-resveratrol (6) and trans-resveratrol-5-O-β-D-glucopyranoside (7) by comparing their physicochemical and spectral data with published data. Compound 3 was isolated for the first time from the Polygonaceae family. Among the purified compounds, 3 showed more potent inhibitory activity against topoisomerase I (IC: 4 μM) than camptothecin, as the positive control (IC: 18 μM). Compounds 3, 4, 5, 6 and 7 showed stronger inhibitory activities toward DNA topoisomerase II (IC: 0.54, 14, 15, 0.77 and 3 μM, respectively) than the positive control, etoposide (IC: 44 μM). Compounds 1 and 4 displayed weak cytotoxicities against human lung cancer (A549), ovarian cancer (SK-OV-3), human liver hepatoblastoma (HepG2) and colon adenocarcinoma (HT-29) cell lines.