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- 저자 : ( Yulia Makarova ) (검색결과 1 건)
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( Alexander Kabakov ),( Yulia Makarova ),( Anna Demidkina ) 대한내과학회 2014 대한내과학회 추계학술발표논문집 Vol.2014 No.1
Background: Endothelial progenitor cells (EPCs) coming from bone marrow into the peripheral circulation promote neovascularization of tumors and development of metastases. In some cases, the levels of circulating EPCs were shown to correlate with response to chemotherapy and may be a biomarker for the drug treatment outcome. Here we examined how the number of circulating EPCs correlates with the effi cacy of radiotherapy and is to be used as a biomarker for the outcome of combined cancer treatment involving radiation exposure. Methods: Circulating EPCs stained with anti-CD34, anti-CD133 or anti-VEGF receptor- 2 antibodies were quantifi ed by fi ow cytometry in the peripheral blood samples of patients with breast or lung cancer. Dozens of those patients were categorized and thoroughly investigated; gender, age, stage/type/size/growth dynamics of tumors, responses to therapy, progression-free survival time periods were analyzed toward correlations with the counted numbers of circulating EPCs. Results: The levels of circulating EPCs were found to be increased in all studied groups of breast and lung cancer patients as compared with healthy donors (n = 36; p < 0.01). The signifi cantly higher levels of EPCs were detected in peripheral blood of patients undergone high-dose (gamma-photon) radiation exposure in the course of combined treatment as compared with patients treated without radiotherapy (n = 48; p < 0.05). Among the irradiated patients, the higher levels of circulating EPCs often coincided with poor response to radiotherapy and poor outcome. In contrast, combination with radiotherapy was considerably more effective in patient groups with the low EPC levels where longer progression-free time periods were achieved. Conclusions: Circulating bone marrow-derived EPCs may be a predictive biomarker for the effi cacy of anticancer therapy and prognosis. Furthermore, EPCs may be a therapeutic target for chemo- and radiosensitization of tumors.
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