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Anti-Melanogenic Effect of Adiponectin on Co-Culture Models and Human Skin Tissues Ex Vivo
( Youngkyoung Lim ),( Myoung Eun Choi ),( Mi Young Lee ),( Hyesoo Cho ),( Seunghyun Bang ),( Sung Eun Chang ) 대한피부과학회 2023 대한피부과학회지 Vol.61 No.1
Background: Adiponectin is an adipose-derived hormone that plays a role in various metabolic diseases. We previously demonstrated that adiponectin inhibits melanin synthesis through adenosine monophosphate-activated protein kinase (AMPK) activation in melanocytes. However, melanocytes can be affected by neighboring keratinocytes, and the effect of adiponectin on these functional units has not been investigated. Objective: We investigated the effect of adiponectin on melanogenesis in co-cultured models of normal human melanocytes (NHMs), normal human keratinocytes (NHKs), and human dermal fibroblasts (HDFs), and the effect of adiponectin on melanin content in human skin tissues. Methods: Quantitative real-time polymerase chain reaction (qPCR) was performed for tyrosinase and microphthalmia-associated transcription factor (MITF). The degree of phosphorylation of AMPK, cAMP response element binding protein (CREB), and AKT was evaluated by western blot assay, and Fontana-Masson staining was performed on cultured human skin tissues. Results: Adiponectin decreased the melanin content in the co-culture models of NHMs with NHKs, NHMs with HDFs, and NHMs with both NHKs and HDFs. qPCR revealed that both tyrosinase and MITF were decreased after adiponectin treatment in the co-culture system. Following adiponectin treatment, AMPK was activated in all cell groups; however, the phosphorylation of CREB was decreased in HDFs and NHKs. The phosphorylation of AKT was decreased in only NHMs. In the experiment with human skin tissues cultured ex vivo, the densitometric analysis of Fontana-Masson staining revealed that adiponectin treatment reduced the melanin level of ultraviolet-irradiated human skin tissues. Conclusion: Adiponectin inhibited melanogenesis in both co-culture models and human skin tissues ex vivo. (Korean J Dermatol 2023;61(1):36∼42)
Two cases of metastatic calcinosis cutis
( Youngkyoung Lim ),( Chan Seong Park ),( Jae Ho Lee ),( You Jin Lee ),( Ji Hye Park ),( Jong Hee Lee ),( Dong Youn Lee ),( Joo Heung Lee ),( Jun Mo Yang ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.1
Calcinosis cutis (CC) represents the deposition of calcium in the skin. CC can be divided into four categories; dystrophic, metastatic, idiopathic and iatrogenic CCs. Dystrophic CC occurs on damaged tissue by various underlying conditions with normal serum level of calcium (Ca) and phosphate (P). Idiopathic CC is not related to any tissue defects or metabolic abnormalities of Ca and P. Iatrogenic CC occurs secondarily by medical procedures such as intravenous administration of Ca or P. Lastly, metastatic CC is related to abnormalities of Ca and P metabolism, and generally associated with hyperphosphatemia and hypercalcemia. Metastatic CC is most commonly associated with chronic renal failure (CRF). We present two cases of metastatic CC. Both patients had underlying CRF with hemodialysis. The first patient was 64-year-old woman having multiple yellowish nodules on her hands which was initially confused with the non-tuberculous mycobacterium (NTM) infection. The second patient, a 53-year-old man, developed a rigid nodule on his finger. The skin specimens presented calcium deposits in the dermis and both of them showed significantly elevated serum P levels. We therefore diagnosed these two cases as metastatic calcinosis cutis.
( Youngkyoung Lim ),( Chan Seong Park ),( Jae Ho Lee ),( You Jin Lee ),( Ji-hye Park ),( Jong Hee Lee ),( Joo-heung Lee ),( Jun-mo Yang ),( Dong-youn Lee ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.2
Background: Cutaneous anaplastic large cell lymphoma (ALCL) can be divided into two groups, primary cutaneous ALCL (PC-ALCL) which initially presents in the skin and cutaneous involvement of systemic ALCL (CIS-ALCL) which is secondary to nodal disease. Objectives: We attempted to assess clinical presentation and prognostic factors of patients with cutaneous ALCL. Methods: This was a retrospective chart review of patients with cutaneous ALCL which had been confirmed with skin biopsy between 1996 and 2016. Results: A total of 25 patients with cutaneous ALCL were included. Fourteen patients had PC-ALCL and eleven showed skin involvement of systemic ALCL. CIS-ALCL was more likely to present with extensive and multiple skin lesions than PC-ALCL, but it was not statistically significant. The prognosis of CIS-ALCL patients was poor. Seven of eleven patients (63.6%) died within a mean survival time of 9.7 months after the confirmation of skin involvement. Leukocyte or C-reactive protein (CRP) elevation in the blood were associated with poorer outcome in CIS-ALCL. Conclusion: In addition to well-known prognostic factors of lymphoma such as B-symptom and increased LDH, having leukocytosis or elevated CRP level may predict poor survival in patient with cutaneous ALCL.
( Youngkyoung Lim ),( Ji Hye Park ),( Dong Youn Lee ),( Jong Hee Lee ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.2
Background: Interest in minimizing scars especially on face has been rising recently. Objectives: We sought to determine which factors are associated with the number of treatment sessions to reach the treatment endpoint (NTSE) when using laser therapy. Methods: An institutional retrospective study of all patients treated with laser for facial scars from 2012 to 2015 was conducted. Treatment methods were determined according to the characteristics of individual scars following an algorithm. In one treatment session, either a 595nm pulse dye laser or a non-ablative fractional laser was used, and corticosteroid injection was combined in some cases. A multivariable linear regression model was built examining NTSE and the interplay of various factors. Results: Eighty four scars were analyzed. The onset of treatment (period between wound occurring and the initiation of treatment) was significantly associated with NTSE (p=0.006). When laser treatment was started for facial scar within 1 month after wound occurring expected less NTSE (p=0.009) and less likely to develop hypertrophic scar (p<0.001). Conclusion: The results of this study can be used to propose optimal treatment guidelines based on various characteristics of scars. Early implementation of laser treatment for scars on face may reduce the number of treatment sessions required for the desirable outcomes.
( Youngkyoung Lim ),( Hyoungmin Na ),( Changjin Jung ),( Miyoung Lee ),( Ikjun Moon ),( Chonghyun Won ) 대한피부과학회 2021 대한피부과학회 학술발표대회집 Vol.73 No.-
Background: In recent years, variable rejuvenation techniques, such as hyaluronic acid (HA) fillers and radiofrequency (RF) devices, have become popular. We evaluated the RF hydro-injector (RFHI) device that simultaneously delivers both a microneedle intradermal RF treatment and a HA filler injection to overcome the disadvantages of HA filler and RF devices alone. Objectives: This study aimed to assess the efficacy and safety of the RFHI device for the rejuvenation of the periorbital area, including the lateral canthal lines (LCLs) and the infraorbital area. Methods: A total of 24 subjects were enrolled in this study and underwent 2 to 3 treatments using the RFHI device. The investigator’s global assessment of the lateral canthal line (IGA-LCL) and the global esthetic improvement scale (GAIS) were used to evaluate the improvement in the LCL. Cutometer<sup>®</sup> was used to evaluate the skin’s elasticity, and the Antera 3D image capture system<sup>®</sup> was used to evaluate the degree of wrinkles, roughness, and pore volume. Results: At the 8 week follow-up after the first treatment session, both the IGA-LCL and GAIS showed significant improvement. The improvement in the wrinkles, roughness, and pore volume, measured by the Antera 3D image capture system<sup>®</sup>, was statistically significant. No serious adverse event was reported. Conclusion: This RFHI device, which delivers both microneedle intradermal RF treatment and HAfiller injection, is effective and safe for periorbital rejuvenation.
A case of yellow nail syndrome with myocardial infarction and hypothyroidism
( Youngkyoung Lim ),( Jongeun Lee ),( Hyun Jeong Byun ),( Chan Seong Park ),( Jae Ho Lee ),( Ji-hye Park ),( Jong Hee Lee ),( Dong-youn Lee ),( Joo-heung Lee ),( Jun-mo Yang ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.1
Yellow Nail Syndrome (YNS) is a rare disorder that almost always occurs after 50 years of age but a juvenile or familial form has also been observed. It is chracterized by yellow nail discoloration, pulmonary manifestations, and lower limb lymphedema. Nail manifestation includes slow growth, thickening, hardening, transversal ridging, onycholysis, onychorrhexis, and paronychia. Pulmonary manifestation shows bronchitis, bronchiectasis, pneumonia, and pleural effusions. Chronic sinusitis is frequently associated with the triad of YNS. A 61-year-old male visited our clinic with nail dystrophy which started 18 months ago. Nail changes were observed including nail thickening, yellow color change, and transverse ridging. Result of potassium hydroxide (KOH) preparation, and fungus culture were negative. Periodic acid-Schiff (PAS) staining of nail clipping specimen revealed no fungal hyphae. There had been history of bronchiectasia with bronchiolitis, pneumonia, and chronic sinusitis. The patient had also experienced myocardial infarction (MI) and hypothyroidism. Herein, we present a very rare case of YNS with both MI and hypothyroidism.
[P246] A case of nail dystrophy with selective IgA deficiency
( Youngkyoung Lim ),( Hyun Jung Byun ),( Chan Seong Park ),( Jae Ho Lee ),( Ji-hye Park ),( Jong-hee Lee ),( Dong-yoon Lee ),( Joo-heung Lee ),( Jun-mo Yang ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.1
Nail is a mirror of our health. Nail dystrophy is very common and associated with various diseases. The causes of nail dystrophies are related to infections (fungus, bacteria, and virus), congenital disorders, environmental inputs (such as trauma and drugs), various cutaneous diseases (psoriasis, lichen planus, eczema, etc.), and systemic conditions. A 4-year-old boy visited our clinic with nail dystrophy which started 4 months ago. Nail changes were observed including onycholysis with oil-drop discoloration, superficial fragility and onychomadesis of the proximal nail plate, Beau’s line, koilonychia, and onychorrhexis. Nail clipping examination for fungus was negative. There has been frequent history of infections such as pneumonia and sinusitis since 4 years ago. Laboratory findings showed decreased serum immunoglobulin A (IgA) level (4mg/dl, reference: 27~195mg/dl) in the presence of normal serum levels of IgG and IgM. He was diagnosed as selective IgA deficiency which is a type of hypogammaglobulinemia. He died of a disseminated enterovirus infection 16 months later. Herein, we present a rare case of nail dystrophy with selective IgA deficiency and discuss the possible significance of this finding.
A case of multiple cutaneous leiomyomas
( Youngkyoung Lim ),( Chan Seong Park ),( Jae Ho Lee ),( You Jin Lee ),( Ji Hye Park ),( Jong Hee Lee ),( Dong Youn Lee ),( Joo Heung Lee ),( Jun Mo Yang ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.1
Cutaneous leiomyomas (CL) are benign smooth muscle tumors, which are also called as piloleiomyomas. CL may occur sporadically or as a cutaneous manifestation of an autosomal dominant genetic syndrome, hereditary leiomyomatosis and renal cell cancer (HLRCC), which was revealed to be associated with fumarate hydratase (FH) gene. HLRCC is associated with multiple CL and uterine leiomyomas in females, and renal cancers. CL may occur more often (76 to 100%) in individuals with the mutation of FH gene than renal cell cancer (about 15 to 20%). HLRCCassociated renal cancers are aggressive, so that dermatological diagnosis of CL is important for renal cancer screening. If possible, genetic study of FH mutation should be considered in individuals with multiple CL. Herein, we report a case of 59-year-old woman who presented painful multiple nodules and papules on her chest and right shoulder. She had a history of hysterectomy 16 years ago due to uterine leiomyoma. From skin biopsy, the specimen showed a wellcircumscribed nodular tumor within the reticular dermis. It presented interlacing bundles of tumor cells with blunt-ended or cigar-shaped nuclei. Tumor cells were positive for SMA, but they were S-100 negative. Finally, the cutaneous lesion was diagnosed as leiomyoma.