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      • KCI등재

        Bag of Visual Words Method based on PLSA and Chi-Square Model for Object Category

        ( Yongwei Zhao ),( Tianqiang Peng ),( Bicheng Li ),( Shengcai Ke ) 한국인터넷정보학회 2015 KSII Transactions on Internet and Information Syst Vol.9 No.7

        The problem of visual words` synonymy and ambiguity always exist in the conventional bag of visual words (BoVW) model based object category methods. Besides, the noisy visual words, so-called “visual stop-words” will degrade the semantic resolution of visual dictionary. In view of this, a novel bag of visual words method based on PLSA and chi-square model for object category is proposed. Firstly, Probabilistic Latent Semantic Analysis (PLSA) is used to analyze the semantic co-occurrence probability of visual words, infer the latent semantic topics in images, and get the latent topic distributions induced by the words. Secondly, the KL divergence is adopt to measure the semantic distance between visual words, which can get semantically related homoionym. Then, adaptive soft-assignment strategy is combined to realize the soft mapping between SIFT features and some homoionym. Finally, the chi-square model is introduced to eliminate the “visual stop-words” and reconstruct the visual vocabulary histograms. Moreover, SVM (Support Vector Machine) is applied to accomplish object classification. Experimental results indicated that the synonymy and ambiguity problems of visual words can be overcome effectively. The distinguish ability of visual semantic resolution as well as the object classification performance are substantially boosted compared with the traditional methods.

      • KCI등재

        Object Classification based on Weakly Supervised E2LSH and Saliency map Weighting

        ( Yongwei Zhao ),( Bicheng Li ),( Xin Liu ),( Shengcai Ke ) 한국인터넷정보학회 2016 KSII Transactions on Internet and Information Syst Vol.10 No.1

        The most popular approach in object classification is based on the bag of visual-words model, which has several fundamental problems that restricting the performance of this method, such as low time efficiency, the synonym and polysemy of visual words, and the lack of spatial information between visual words. In view of this, an object classification based on weakly supervised E2LSH and saliency map weighting is proposed. Firstly, E2LSH (Exact Euclidean Locality Sensitive Hashing) is employed to generate a group of weakly randomized visual dictionary by clustering SIFT features of the training dataset, and the selecting process of hash functions is effectively supervised inspired by the random forest ideas to reduce the randomcity of E2LSH. Secondly, graph-based visual saliency (GBVS) algorithm is applied to detect the saliency map of different images and weight the visual words according to the saliency prior. Finally, saliency map weighted visual language model is carried out to accomplish object classification. Experimental results datasets of Pascal 2007 and Caltech-256 indicate that the distinguishability of objects is effectively improved and our method is superior to the state-of-the-art object classification methods.

      • KCI등재

        Tip60 and p300 function antagonistically in the epigenetic regulation of HPV18 E6/E7 genes in cervical cancer HeLa cells

        Yongwei Lai,Zhao He,Aowei Zhang,Zhinan Yan,Xiao Zhang,Shiyue Hu,Nan Wang,Hongpeng He 한국유전학회 2020 Genes & Genomics Vol.42 No.6

        Background High-risk HPV is a causative factor of cervical cancer. HPV DNA fragments integrate into host genome resulting in the constitutive expression of HPV genes E6 and E7 under the regulation of transcription factors, such as p300 and Tip60. Interestingly, Tip60, a factor with HAT (histone acetyl transferase) activity, represses HPV18 E6/E7 genes while another HAT p300 activates the transcription of HPV18 E6/E7. Objective To explore the mechanism for the opposite roles of Tip60 and p300 in the virus gene regulation, and the influence of Tip60 and p300 in histone modifications in the regulatory sequence of HPV18 genes. Methods Tip60 or p300 was either knocked down or overexpressed in HeLa cells. The effects on HPV E6E7 expression were determined with RT-qPCR. The association of RNA polymerase II and the enrichment of acetylated or methylated histones in HPV promoter region were measured by ChIP assays with specific antibodies. Results ChIP results showed that Tip60 and p300 differently affected the modifications of histone H3K9 and the deposition of nucleosomes in HPV18 long control region (LCR). HPV18 LCR in HeLa cells is bivalent chromatin carrying both the active histone H3K9 acetylation mark and the repressive histone H3K9 trimethylation mark, the balance is maintained by Tip60 and p300. Conclusion(s) Based on the roles of Tip60 and p300 in HPV gene regulation, chemical compounds targeting Tip60 or p300 are potential anti-cervical cancer drugs.

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