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Anti-dementia Activity of Nobiletin, a Citrus Flavonoid: A Review of Animal Studies
Akira Nakajima,Kiyofumi Yamada,Yasushi OHIZUMI 대한정신약물학회 2014 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.12 No.2
Alzheimer’s disease (AD), the most common form of dementia among the elderly, is characterized by the progressive declineof cognitive function and has a detrimental impact worldwide. Despite intensive laboratory and clinical research over the lastthree decades, pharmacological options for the prevention and effective long-term treatment of AD are not currently available. Consequently, successful therapeutic and preventive treatments for AD are needed. When researching materials from naturalresources having anti-dementia drug activity, we identified nobiletin, a polymethoxylated flavone from the peel of Citrus depressa. Nobiletin exhibited memory-improving effects in various animal models of dementia and exerted a wide range of beneficial effectsagainst pathological features of AD including amyloid-β (Aβ) pathology, tau hyperphosphorylation, oxidative stress, cholinergicneurodegeneration and dysfunction of synaptic plasticity-related signaling, suggesting this natural compound could become anovel drug for the treatment and prevention of AD.