Perturbed three-step iterative processes witherrors for general strongly nonlinear quasivariationalinequalities

Yali Zhao,Zeqing Liu,Shin Min Kang,Zunquan Xia 한국전산응용수학회 2005 Journal of applied mathematics & informatics Vol.17 No.1-2

In this paper, we introduce and study a class of general strongly nonlinear quasivariational inequalities in Hilbert spaces. We prove the existence and uniqueness of solution and convergence of the perturbed the three-step iterative sequences with errors for this kind of general strongly nonlinear quasivariational inquality problems involving relaxed Lipschitz, relaxed monotone, and strongly monotone mappings. Our results extend, improve, and unify many known results due to Liu-Ume-Kang, Kim-Kyung, Zeng and others

PERTURBED THREE-STEP ITERATIVE PROCESSES WITH ERRORS FOR GENERAL STRONGLY NONLINEAR QUASIVARIATIONAL INEQUALITIES

ZHAO, YALI,XIA, ZUNQUAN,LIU, ZEQING,KANG, SHIN MIN 한국전산응용수학회 2005 Journal of applied mathematics & informatics Vol.17 No.1

In this paper, we introduce and study a class of general strongly nonlinear quasivariational inequalities in Hilbert spaces. We prove the existence and uniqueness of solution and convergence of the perturbed the three-step iterative sequences with errors for this kind of general strongly nonlinear quasivariational inquality problems involving relaxed Lipschitz, relaxed monotone, and strongly monotone mappings. Our results extend, improve, and unify many known results due to Liu-Ume-Kang, Kim-Kyung, Zeng and others.

Panduratin A Inhibits Cell Proliferation by Inducing G0/G1 Phase Cell Cycle Arrest and Induces Apoptosis in Breast Cancer Cells

( Qiuming Liu,Yali Cao ),( Ping Zhou ),( Shimin Gui ),( Xiaobo Wu ),( Yong Xia ),( Jianhong Tu ) 한국응용약물학회 2018 Biomolecules & Therapeutics(구 응용약물학회지) Vol.26 No.3

Because of the unsatisfactory treatment options for breast cancer (BC), there is a need to develop novel therapeutic approaches for this malignancy. One such strategy is chemotherapy using non-toxic dietary substances and botanical products. Studies have shown that Panduratin A (PA) possesses many health benefits, including anti-inflammatory, anti-bacterial, anti-oxidant and anticancer activities. In the present study, we provide evidence that PA treatment of MCF-7 BC cells resulted in a time- and dosedependent inhibition of cell growth with an IC< SUB >50< /SUB > of 15 μM and no to little effect on normal human MCF-10A breast cells. To define the mechanism of these anti-proliferative effects of PA, we determined its effect critical molecular events known to regulate the cell cycle and apoptotic machinery. Immunofluorescence and flow cytometric analysis of Annexin V-FITC staining provided evidence for the induction of apoptosis. PA treatment of BC cells resulted in increased activity/expression of mitochondrial cytochrome C, caspases 7, 8 and 9 with a significant increase in the Bax:Bcl-2 ratio, suggesting the involvement of a mitochondrial-dependent apoptotic pathway. Furthermore, cell cycle analysis using flow cytometry showed that PA treatment of cells resulted in G0/G1 arrest in a dose-dependent manner. Immunoblot analysis data revealed that, in MCF-7 cell lines, PA treatment resulted in the dosedependent (i) induction of p21^WAF1/Cip1 and p27Kip1, (ii) downregulation of Cyclin dependent kinase (CDK) 4 and (iii) decrease in cyclin D1. These findings suggest that PA may be an effective therapeutic agent against BC.

Ergonomic Study of Mattress Firmness by Measuring Spinal Curve and Sleep Quality

( Tetsuo Katsuura ),( Masaki Teshima ),( Yali Xia ),( Soomin Lee ),( Yoshika Takahashi ),( Ikuo Asai ),( Yoshihiro Shimomura ) 한국감성과학회 2014 춘계학술대회 Vol.2014 No.-

We examined the influence of mattress firmness on the spinal curve, sleep quality, and subjective evaluations in healthy subjects. The firmness of the three equal parts of air /mattress was controlled by the air pressure in each part. In Experiment 1, we created nine air mattress conditions by setting the air pressure of each of the upper and middle parts at 4, 6, or 8 kPa, and that of the lower part at 6 kPa. We measured the spinal curves of 10 healthy young male subjects from the coccyx to the 7th cervical vertebra by a fiber optic-based 3D bend and twist sensor, while they laid down on their right side with the angle of the trunk and thigh at 135º (abbreviated as lying135º) and when they laid supine, in each of the nine mattress conditions. We found that the spinal curve during supine position with the conditions of lower part: 6 kPa, middle: 4 kPa, and upper: 6 kPa (6:4:6) was the most similar to that during lying135º, which makes the spinal curve natural. However, the subjective evaluation of comfort of the mattress by a visual analog scale (VAS) scored highest in the 6:4:8 condition.

Panduratin A Inhibits Cell Proliferation by Inducing G0/G1 Phase Cell Cycle Arrest and Induces Apoptosis in Breast Cancer Cells

Liu, Qiuming,Cao, Yali,Zhou, Ping,Gui, Shimin,Wu, Xiaobo,Xia, Yong,Tu, Jianhong The Korean Society of Applied Pharmacology 2018 Biomolecules & Therapeutics(구 응용약물학회지) Vol.26 No.3

Because of the unsatisfactory treatment options for breast cancer (BC), there is a need to develop novel therapeutic approaches for this malignancy. One such strategy is chemotherapy using non-toxic dietary substances and botanical products. Studies have shown that Panduratin A (PA) possesses many health benefits, including anti-inflammatory, anti-bacterial, anti-oxidant and anticancer activities. In the present study, we provide evidence that PA treatment of MCF-7 BC cells resulted in a time- and dose-dependent inhibition of cell growth with an $IC_{50}$ of $15{\mu}M$ and no to little effect on normal human MCF-10A breast cells. To define the mechanism of these anti-proliferative effects of PA, we determined its effect critical molecular events known to regulate the cell cycle and apoptotic machinery. Immunofluorescence and flow cytometric analysis of Annexin V-FITC staining provided evidence for the induction of apoptosis. PA treatment of BC cells resulted in increased activity/expression of mitochondrial cytochrome C, caspases 7, 8 and 9 with a significant increase in the Bax:Bcl-2 ratio, suggesting the involvement of a mitochondrial-dependent apoptotic pathway. Furthermore, cell cycle analysis using flow cytometry showed that PA treatment of cells resulted in G0/G1 arrest in a dose-dependent manner. Immunoblot analysis data revealed that, in MCF-7 cell lines, PA treatment resulted in the dose-dependent (i) induction of $p21^{WAF1/Cip1}$ and p27Kip1, (ii) downregulation of Cyclin dependent kinase (CDK) 4 and (iii) decrease in cyclin D1. These findings suggest that PA may be an effective therapeutic agent against BC.

Ergonomic Study of Mattress Firmness by Measuring Spinal Curve and Sleep Quality

Tetsuo Katsuura,Masaki Teshima,Yali Xia,Soomin Lee,Yoshika Takahashi,Ikuo Asai,Yoshihiro Shimomura 대한인간공학회 2014 대한인간공학회 학술대회논문집 Vol.2014 No.5

We examined the influence of mattress firmness on the spinal curve, sleep quality, and subjective evaluations in healthy subjects. The firmness of the three equal parts of air /mattress was controlled by the air pressure in each part. In Experiment 1, we created nine air mattress conditions by setting the air pressure of each of the upper and middle parts at 4, 6, or 8 kPa, and that of the lower part at 6 kPa. We measured the spinal curves of 10 healthy young male subjects from the coccyx to the 7th cervical vertebra by a fiber optic-based 3D bend and twist sensor, while they laid down on their right side with the angle of the trunk and thigh at 135° (abbreviated as lying135°) and when they laid supine, in each of the nine mattress conditions. We found that the spinal curve during supine position with the conditions of lower part: 6 kPa, middle: 4 kPa, and upper: 6 kPa (“6:4:6”) was the most similar to that during lying135°, which makes the spinal curve natural. However, the subjective evaluation of "comfort of the mattress" by a visual analog scale (VAS) scored highest in the 6:4:8 condition. As Experiment 2, we compared sleep quality achieved with the 6:4:6 and 6:4:8 conditions over each of seven consecutive nights (three adaptation nights and four for analysis) in subjects’ homes. The sleep quality achieved by 20 healthy adult males and females was assessed by means of actigraphy, the standardized Oguri-Shirakawa-Azumi (OSA) Sleep Inventory (middle-aged version), and VAS subjective evaluations. The estimated sleep quality measured on the 6:4:6 mattresses was significantly higher than that on the 6:4:8 mattress. The VAS evaluations of "comfort of the lower back" and "comfort of the upper back" were also higher for the 6:4:6 mattress. There were no significant differences in the OSA scores between mattress conditions. Our results indicate that the 6:4:6 mattress condition, which appeared to provide a natural spinal curve, provided higher sleep quality and higher subjective evaluations during actual use compared to the 6:4:8 condition.