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- 저자 : ( Vikash Gautam ) (검색결과 1 건)
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( Vikash Gautam ),( Dilip Thakur ),( Bishnu Hari Paudel ),( Kopila Agrawal ),( Madhab Lamsal ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: To correlate brainstem auditory evoked potentials` (BAEPs) amplitude and latency within different thyroid status (hypothyroidism, hyperthyroidism and euthyroidism). Methods: BAEP and Thyroid Function Tests (TFT) were assessed in consenting 75 subjects (hypothyroid=24, hyperthyroid=25, euthyroid= 26). The mean age in hypothyroid, hyperthyroid, and euthyroid group were 31.46±4.191; 31.52±4.134 and 27.12±2.732 respectively. The BAEP parameters viz, wave I-V latencies, interpeak latencies and amplitudes were recorded. One way ANOVA was used to compare BAEP parameters among three groups and Pearson`s correlation to fi nd relation between thyroid hormones (fT3, fT4, TSH) and BAEP parameters. P value less than 0.05 was considered statistically signifi cant. Results: Wave I (1.78±0.21 vs. 1.64±0.22, vs. 1.56±0.15, p= 0.001), wave III (3.96±0.19 vs. 3.90±0.30 vs. 3.74±0.30, p= 0.001) and wave V (5.97±0.36 vs. 5.91±0.37 vs. 5.60±0.24; p= 0.001) latencies (ms) were signifi cantly more in hypothyroid and hyperthyroid than euthyroid. Wave interval latencies (ms) III-V (2.01±0.32 vs. 2.01±0.41 vs. 1.86±0.32, p= 0.044) and I-V (4.19±0.43 vs. 4.26±0.41 vs. 4.03±0.28, p= 0.007) were longer in hypothyroid and hyperthyroid than euthyroid. Also, the wave I-V amplitude (μV) was more in hypo-hyperthyroid than euthyroid (0.15±0.11 vs. 0.22±0.17 vs. 0.20±0.16, p= 0.052). TSH & Wave I-V amplitude (r= -0.193, p= 0.04); fT3 and wave I latency (r= -0.269, p=0.004) were negatively correlated. However, a positive correlation was between TSH & wave I latency (r= 0.285, p=0.002). Conclusion: Both hypo- and hyperthyroidism led to conduction delay in auditory neurons in adults, possibly adversely affecting function of myelin since, T3 and T4 are known to affect myelinization and synaptic transmission. The prominent auditory evoked potential abnormalities in hypothyroidism and less change in hyperthyroidism are consistent with a possibility that the auditory neuropathy is more common in thyroid defi ciency than its excess.
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