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- 저자 : ( Tongxiang Song ) (검색결과 1 건)
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( Tongxiang Song ),( Xuelin Zhao ),( Yina Shao ),( Ming Guo ),( Chenghua Li ),( Weiwei Zhang ) 한국미생물생명공학회(구 한국산업미생물학회) 2019 Journal of microbiology and biotechnology Vol.29 No.6
It is well known that iron is critical for bacterial growth and pathogenic virulence. Due to chemical similarity, Ga<sup>3+</sup> competes with Fe3+ for binding to compounds that usually bind Fe<sup>3+</sup>, thereby interfering with various essential biological reactions. In our present study, gallium(III) nitrate [Ga(NO<sub>3</sub>)<sub>3</sub>] could repress the growth of V. splendidus Vs without complete inhibition. In the presence of Ga(NO<sub>3</sub>)<sub>3</sub>, the secretion of homogentisic acid-melanin (HGAmelanin) in V. splendidus Vs cells could be increased by 4.8-fold, compared to that in the absence of Ga(NO<sub>3</sub>)<sub>3</sub>. HGA-melanin possessed the ability to reduce Fe<sup>3+</sup> to Fe<sup>2+</sup>. In addition, HGA-melanin increased the mRNA levels of feoA and feoB, genes coding Fe2+ transport system proteins to 1.86- and 6.1-fold, respectively, and promoted bacterial growth to 139.2%. Similarly, the mRNA expression of feoA and feoB was upregulated 4.11-fold and 2.71-fold in the presence of 640 μM Ga(NO<sub>3</sub>)<sub>3</sub>, respectively. In conclusion, our study suggested that although Ga(NO<sub>3</sub>)<sub>3</sub> could interfere with the growth of V. splendidus Vs, it could also stimulate both the production of Fe<sup>3+</sup>-reducing HGA-melanin and the expression of feoA and feoB , which facilitate Fe<sup>2+</sup> transport in V. splendidus Vs.
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