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Development of ciclopirox nail lacquer with enhanced permeation and retention
( Raj Kumar Thapa ),( Ju Yeon Choi ),( Toe Gyung Go ),( Min Hyung Kang ),( Sang Duk Han ),( Joon Ho Jun ),( Mi Won Son ),( Chul Soon Yong ),( Jong Oh Kim ) 영남대학교 약품개발연구소 2016 영남대학교 약품개발연구소 연구업적집 Vol.26 No.-
Onychomycosis is a prevailing disease caused by fungal infection of nails that mostly affects athletes and the elderly. Ciclopirox is approved by the US Food and Drug Administration for the topical treatment of ony-chomycosis. However, the desired penetration of ciclopirox into the nail bed has not been achieved via topical appli-cation for efficient treatment. Therefore, the main aim of this study was to enhance ciclopirox permeation and retention in nail by the development of a new nail lacquer formulation. We screened the effects of different solvents, alkalizing agents, and permeation enhancers on the per-meation of bovine hooves by ciclopirox and its retention in human nail clippings. The results suggest that isopropyl alcohol, potassium hydroxide, and urea as the solvent, alkalizing agent, and permeation enhancer, respectively, improved the permeation of the ciclopirox nail lacquer formulation the most with high flux rates. Comparison of the final formulation and marketed product revealed enhanced retention of ciclopirox from our developed for-mulation in human nail clippings. Therefore, our newly developed nail lacquer may be a potentially effective for-mulation for the treatment of onychomycosis in humans.
( Sung Guy Jin ),( Kyeong Soo Kim ),( Dong Wuk Kim ),( Dong Shik Kim ),( Youn Gee Seo ),( Toe Gyung Go ),( Yu Seok Youn ),( Jong Oh Kim ),( Chul Soon Yong ),( Han Gon Choi ) 영남대학교 약품개발연구소 2016 영남대학교 약품개발연구소 연구업적집 Vol.26 No.-
To develop a novel sodium fusidate-Ioaded triple polymer hydrogel dressing (TPHD). numerious polyvinyl alcohol-based (PVA) hydrogel dressings were prepared with various hydrophilic polymers using the freeze-thaw method. and their hydrogel dressing properties were assessed. Among the hydrophilic polymers tested, sodium alginate (SA) improved the swelling capacity the most, and polyvinyl pyrrolidone (PVP) provided the greatest improvement in bioadhesive stength and mechanical properties. Thus, PVA based-TPHDs were prepared using different ratios of PVP:SA The effect of selected PVP:SA ratios on the swelling capacity, bioadhesive strength, mechanical properties, and drug release, permeation and deposition characteristics of sodium fusidate-Ioaded PVA-based TPHDs were assessed. As the ratio of PVP:SA increased in PVA-Ioaded TPHD, the swelling capacity, mechanical properties, drug release. permeation and deposition were improved. The TPHD containing PVA. PVP, SA and sodium fusidate at the weight ratio of 10/6/1/1 showed excellent hydrogel dressing properties. release. permeation and deposition of drug. Within 24 h, 71.8 ± 1.3% of drug was released. It permeated 625.1 ±81.2μg/cm<sub>2</sub> through the skin and deposited of 313.8 ± 24.1 fLgfcm2 within 24 h. The results of in vivo pharmacodynamic studies showed that sodium fusidate-Ioaded TPHD was more effective in improving the repair process than was a commercial product. Thus, this sodium fusidate-Ioaded TPHD could be a novel tool in wound care.