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      • Poster Session:PS 0560 ; Oncology : Infi ltrative Ductal Breast Carcinoma: Correlation Between Immunohistochemical Markers and Histopathological Pattern

        ( Tatyana Kunts ),( Ksenia Karpukhina ),( Dmitry Morozov ),( Maria Pustovetova ) 대한내과학회 2014 대한내과학회 추계학술발표논문집 Vol.2014 No.1

        Background: Several immunohistochemical markers are known to predict the biological behavior of breast cancer and assess tumor aggressiveness. In particular, ER and PR receptors concern the occurrence of autocrine and paracrine processes that respond to estrogen and progesterone. Ki67 is a nuclear protein, marker proliferative activity of the tumor, high Ki67 usually correlates with a poor prognosis in breast cancer. There has been interest to observe the expression of immunohistochemical markers in comparison to histopathological features of infi ltrative ductal breast carcinoma. Methods: The study was carried out on the samples from 34 patients with infi ltrative ductal carcinoma. Scheme was elaborated to describe histopathological picture including following points: presence of tumor cells within blood vessels, cell infi ltration (lymphocytes, macrophages and granulocytes), the number of mitoses, the ratio of cell elements at various differentiation stage, vascularization, histological type of tumor, the number of affected lymph nodes. Steroid receptors and Ki67 expression were analyzed by immunohistochemical means. Statistical analysis was performed using Spearman`s nonparametric rank correlation coeffi cient test. Results: Proliferation marker Ki67 was directly connected with the presence of tumor cells within blood vessels (r=0.343, p=0.05), granulocytic cell infi ltration of the tumor (r=0,363, p=0.03), aberrant mitoses (r=0,423, p=0.01), relative immature cells content in the tumor (r=0.543, p=0.001). An inverse correlation between Ki67 and relative content of highly differentiated cells in the tumor (r= -0.388, p=0.02) was revealed. ER and PR indexes demonstrated direct correlation with the number of lymph nodes affected by metastases (r=0.468, p=0.005 and r=0.521, p=0.002, respectively). Conclusions: findings suggest expression of estrogen receptor, progesterone receptor and Ki67 are related to histopathological pattern of infi ltrative ductal breast carcinoma. Consequently, results of immunohistochemical analysis conducted on samples obtained by core biopsy should be used to evaluate tumor severity before the surgery.

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