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      • Changes in serum IgE level according to age in patients with atopic dermatitis in Korea

        ( Min Wha Choi ),( Young Shin Kim ),( June Hyunkyung Lee ),( Tai Kyung Noh ),( Tae Young Han ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.2

        Background: Atopic dermatitis is a paradigmatic chronic inflammatory skin disease characterized by a complex pathophysiology. The clinical feature of atopic dermatitis varies depending on the age of the patient. Serum IgE level is useful biomarker to appreciate the sensitization profile of patient with allergic diseases. Objectives: We investigated to identify the changes in serum IgE level according to age in patients with atopic dermatitis in Korea. Methods: We included 779 patients who were diagnosed with atopic dermatitis according to the criteria of Hanifin & Rajka and tested serum IgE level registered Department of Dermatology, Nowon Eulji Medical Center between January 2013 and May 2018. We defined serum IgE level under 200 kU/L indicate intrinsic atopic dermatitis and 200kU/L or/and above indicate extrinsic atopic dermatitis. Results: The patients with intrinsic atopic dermatitis were more common until early childhood (2-6 years). From childhood, percentage of extrinsic atopic dermatitis began to increase to 51.3%. In adolescent, patients with extrinsic atopic dermatitis were twice as many as those with intrinsic atopic dermatitis and 1.22 times more in young adult. From adult, the proportion of patient with intrinsic atopic dermatitis increased again. Conclusion: We suggest that there might be some associations between changes of clinical feature of atopic dermatitis and changes of serum IgE level according to age.

      • Pain relief effect of anaesthetic cream in cryotherapy of plantar and palmar wart

        ( Min Wha Choi ),( Tai Kyung Noh ),( Tae Young Han ),( June Hyunkyung Lee ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.2

        Background: Among the therapeutic modalities of plantar and palmar wart, cryotherapy using liquid nitrogen is probably the most common method. However, the pain experienced by the patient can be limiting factor in the effective use of cryotherapy. Objectives: We investigated the effectiveness of analgesia provided by a single application of anaesthetic cream after cryotherapy of wart. Methods: This study included patients with plantar and palmar warts who received cryotherapy. All patients were randomized to receive either anaesthetic cream or placebo. For each patient anaesthetic cream or placebo was applied during 1 hour under occlusion immediately after cryotherapy. Pain was evaluated 3 times using visual analogue scale at immediately after cryotherapy, 2 minutes after cream application and 1 hour after cream application. Results: The 88 patients were randomized to receive either anaesthetic cream or placebo. There was no statistically significant difference in visual analogue scale at 2 minutes after cream application between groups. However, the patients with anaesthetic cream experienced significant less pain at 1hour after cryotherapy compared to placebo. Conclusion: We found that effectiveness of analgesia provided by a single application of anaesthetic cream after cryotherapy of wart and we were expecting that reduced pain lead to improve effectiveness of treatment.

      • A case of cutaneous myxoma accompanied with pilomatricoma

        ( Min Wha Choi ),( Byeol Han ),( June Hyunkyung Lee ),( Tae Young Han ),( Tai Kyung Noh ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.1

        Solitary cutaneous myxomas are uncommon benign tumors that are typically presented either as a solitary lesion or as a component of Carney complex. Solitary cutaneous myxomas have rarely been associated with other cutaneous tumors. A 13-year-old Korean male patient presented with well-defined slowly enlarging soft erythematous asymptomatic nodule on the upper back in 6 months’ duration. During the biopsy procedure, we found that there was a palpable deeply seated firm nodule under the soft nodule. Histopathologic examination demonstrated that the superficial soft nodular lesion is a superficial cutaneous myxoma with underlying pilomatricoma. The patient did not show any further evidence of Carney complex through clinical examination. Herein, we report a case of an unusual and unique association of superficial cutaneous myxoma with pilomatricoma.

      • A case of solid facial edema treated with isotretinoin and steroids

        ( Min Wha Choi ),( June Hyunkyung Lee ),( Tai Kyung Noh ),( Tae Young Han ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.1

        Solid facial edema is a rarely described skin condition most commonly associated with acne vulgaris. The clinical presentation is localized symmetric non-pitting painless edema over the forehead, mid-face, nasolabial fold, and cheek. The pathogenesis is not well defined, making this condition difficult to treat. Recently, oral antibiotics, steroids, isotretinoin, and surgical procedures have been used. Despite various kinds of therapy, the effect is minimal and lesions persist in most cases. A 18-year-old man was referred to our department for diffuse swelling on his forehead and both cheeks persisting for 1 year. There was no history of drug hypersensitivity, food allergy, or similar complaints in his family. He had a medical history of acne. Routine laboratory tests including C1 esterase inhibitor level were within normal range. A skin biopsy taken from the cheek revealed dermal fibrosis and papillary dermal edema with inflammatory cells infiltration. Based on the patient’s clinicopathological correlation, we diagnosed solid facial edema. The patient was administered oral isotretinoin 20mg daily and methylprednisolone 8mg for 1week, 4mg for 1week and 2mg for 2weeks. After 6 months of therapy, the edema improved. Herein, we report a case of solid facial edema treated with isotretinoin and steroids.

      • A case of rosuvastatin-induced generalized drug eruption

        ( Min Wha Choi ),( June Hyunkyung Lee ),( Tai Kyung Noh ),( Tae Young Han ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.1

        Statins are one of the most frequently prescribed drugs worldwide due to their benefits in prevention of coronary heart disease. Rosuvastatin represents an advancement on the pharmacologic and clinical properties of other statins. Cutaneous reactions are uncommon adverse effects of statins. To our knowledge, only one case of rosuvastatin-induced erythematous eruptions has been reported and this is the first case report of generalized drug eruptions. A 45-year-old man was referred to our department for erythematous eruption on the whole body, which started 3 days earlier and had exacerbated after he played golf outdoors 5 hours before. Physical examination showed erythematous patches and bullae on the trunk and extremities. The patient had hyperlipidemia and had started taking rosuvastatin 1 week earlier. He had no medical history. Routine laboratory tests showed mild leukocytosis. A skin biopsy revealed intraepidermal bullae with neutrophilic, lymphocytic, and eosinophilic infiltration. We speculated that the drug eruption was due to rosuvastatin. After 2 weeks of oral methylprednisolone therapy and rosuvastatin discontinuation, the lesions improved with hyperpigmentation. However, one week later, the patient restarted rosuvastatin, and the generalized eruption reappeared. Therefore, we diagnosed the patient with rosuvastatin-induced drug eruption. Herein, we report the rare case of Rosuvastatin-induced generalized drug eruption.

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      • KCI등재

        강원도 대관령 목장 현존식생 및 식물군집구조

        노태환 ( Tai Hwan Noh ),한봉호 ( Bong Ho Han ),김종엽 ( Jong Yup Kim ),이민영 ( Min Young Lee ),유기준 ( Ki Joon Yoo ) 한국환경생태학회 2013 한국환경생태학회지 Vol.27 No.5

        본 연구는 온대 북부 기후대에 위치한 강원도 대관령 목장 산림생태계의 현존식생, 식물군집구조, 천이계열 특성과 보전가치를 밝히고, 향후 복원 및 관리계획 수립 시 필요한 기초자료를 제공하고자 수행하였다. 현존식생은 총 56개 유형으로 분류되었고, 조사면적 19,397,361㎡ 중 신갈나무가 우점하는 지역은 7,669,593㎡(39.1%), 1차 초지 지역은 4,785,417㎡(24.7%), 신갈나무-낙엽활엽수군집이 우점하는 지역은 2,182,276㎡(11.3%)이었다. 조사구는 20m×20m (400㎡) 28개소를 설정하였으며, DCA분석 결과 군집 Ⅰ(소나무-신갈나무군집), 군집 Ⅱ(신갈나무-소나무군집), 군집 Ⅲ(신갈나무군집), 군집 Ⅳ(신갈나무-낙엽활엽수군집), 군집 Ⅴ(낙엽활엽수군집), 군집 Ⅵ(팥배나무군집) 등 6개의 식물군집으로 분류되었다. 표본목 수령은 군집 Ⅰ은 57~62년생, 군집 Ⅱ는 41~77년생, 군집 Ⅲ은 47~108년생, 군집 Ⅳ는 47~82년생, 군집 Ⅴ는 47년생, 군집 Ⅵ은 55년생으로 전체적으로 41~108년생이었다. 대관령 목장의 생태적 천이는 소나무군집에서 신갈나무군집으로 발달하고 있는 것으로 예측되었으며, 계곡부를 중심으로 낙엽활엽수군집도 분포하고 있었다. 단위면적 400㎡당 샤논의 종다양도지수를 분석한 결과, 군집 Ⅳ(0.8203~1.1439) → 군집 Ⅲ(0.8019~1.1375) → 군집 Ⅴ(1.0993) → 군집 Ⅰ(0.9475~1.0797) → 군집 Ⅱ(0.6896~1.0324) → 군집 Ⅵ(0.9909) 순으로 높았다. This study was carried out to investigate the actual vegetation, the structure of plant community, and ecological succession sere of forest ecosystem in temperate northern climate zone, Daegwallyeong Ranch, Gangwon-do (Province) and to offer the basic data for planning of the forest managemant. As a result of analysis of actual vegetation, vegetation types divided into 56types and the area of survey site was 19,397,361㎡. The ratio of vegetation type dominated by Quercus mongolica forest was 39.1%, primary grassland was 24.7%, Quercus mongolica-Deciduous broad-leaved forest was 11.3%. Twenty eight plots (size is 20m×20m) were set up and the results analyzed by DCA which in one of the ordination technique showed that the plant communities were divided into six groups which area community Ⅰ (Pinus densiflora-Quercus mongolica community), community Ⅱ (Quercus mongolica-Pinus densiflora community), community Ⅲ (Quercus mongolica community), community Ⅳ (Quercus mongolica-Deciduous broad-leaved community), community Ⅴ (Deciduous broad-leaved community), community Ⅵ (Sorbus alnifolia community). The age of community Ⅰwas ranged from 57 to 62 years old, that of community Ⅱ was ranged from 41 to 77 years old, community Ⅲ was ranged from 47 to 108 years old, community Ⅳ was ranged from 47 to 82 years old, community Ⅴ was 47 years old, community Ⅵ was 55 years old, thus we supposed that the age of the study site is about from 41 to 108 years old. The Ecological succession is predicted from Pinus densiflora community to Quercus mongolica community and Deciduous broad-leaved were distributed in the center of the valley in Daegwallyeong Ranch. According to the index of Shannon``s diversity (unit: 400㎡), community Ⅳ was ranged from 0.8203 to 1.1439, community Ⅲ was ranged from 0.8019 to 1.1375, community Ⅴ was 1.0993, community Ⅰ was ranged from 0.9475 to 1.0797, community Ⅱ was ranged from 0.6896 to 1.0324, community Ⅵ was 0.9909.

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