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Tetraspanin 3 Is Required for the Development and Propagation of Acute Myelogenous Leukemia
Kwon, H.,Bajaj, J.,Ito, T.,Blevins, A.,Konuma, T.,Weeks, J.,Lytle, Nikki K.,Koechlein, Claire S.,Rizzieri, D.,Chuah, C.,Oehler, Vivian G.,Sasik, R.,Hardiman, G.,Reya, T. Cell Press 2015 Cell stem cell Vol.17 No.2
Acute Myelogenous Leukemia (AML) is an aggressive cancer that strikes both adults and children and is frequently resistant to therapy. Thus, identifying signals needed for AML propagation is a critical step toward developing new approaches for treating this disease. Here, we show that Tetraspanin 3 is a target of the RNA binding protein Musashi 2, which plays a key role in AML. We generated Tspan3 knockout mice that were born without overt defects. However, Tspan3 deletion impaired leukemia stem cell self-renewal and disease propagation and markedly improved survival in mouse models of AML. Additionally, Tspan3 inhibition blocked growth of AML patient samples, suggesting that Tspan3 is also important in human disease. As part of the mechanism, we show that Tspan3 deficiency disabled responses to CXCL12/SDF-1 and led to defects in AML localization within the niche. These identify Tspan3 as an important regulator of aggressive leukemias and highlight a role for Tspan3 in oncogenesis.
C.K. How,Moonis Ali Khan,Soraya Hosseini,T.G. Chuah,Thomas S.Y. Choong 한국공업화학회 2014 Journal of Industrial and Engineering Chemistry Vol.20 No.6
Carbon coating onto monolith through soft-template approach have been accomplished by means ofevaporative induced self-assembly (EISA). Variation in acid and alcohol content on monolith’s surfaceproperties was studied, while b-carotene was used as a modelled adsorbate. The pore architecture ofadsorbent samples was analysed through corresponding surface chemistry, N2 sorption isotherm, poresize distribution (PSD) plot, Brunauer–Emmett–Teller (BET), Barett–Joyner–Halenda (BJH) model andscanning electron microscopy (SEM). SEM images displayed a well-covered interconnected worm-likeframework of carbonaceous materials over monolith surface. Surface chemistry studies revealeddominance of acid functionalities over adsorbent samples surface, while basic functionalities remainunaltered. Carbon loading increased with increase in acid concentration, while it decreased withincrease in alcohol content. The adsorbent surface area decreased with increase in acid concentrationand alcohol content. The b-carotene adsorption capacities on synthesized samples varied between179.60 (optimum) and 112.56 mg/g (lower), respectively. Optimum b-carotene adsorption wasobserved on samples MC0.2 and MC5 with alcohol and acid content of 5 mL and 0.2 mL, respectively.