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( Qianqian Pang ),( Yuming Wang ),( Mingyuan Xu ),( Jiachao Xu ),( Shengquan Xu ),( Yichen Shen ),( Jinghong Xu ),( Rui Lei ) 생화학분자생물학회(구 한국생화학분자생물학회) 2019 BMB Reports Vol.52 No.3
Keloids are the most common pathological form of trauma healing, with features that seriously affect appearance and body function, are difficult to treat and have a high recurrence rate. Emerging evidence suggests that miRNAs are involved in a variety of pathological processes and play an important role in the process of fibrosis. In this study, we investigated the function and regulatory network of miR-152-5p in keloids. The miRNA miR-152-5p is frequently downregulated in keloid tissue and primary cells compared to normal skin tissue and fibroblasts. In addition, the downregulation of miR-152-5p is significantly associated with the proliferation, migration and apoptosis of keloid cells. Overexpression of miR-152-5p significantly inhibits the progression of fibrosis in keloids. Smad3 is a direct target of miR-152-5p, and knockdown of Smad3 also inhibits fibrosis progression, consistent with the overexpression of miR-152-5p. The interaction between miR-152-5p and Smad3 occurs through the Erk1/2 and Akt pathways and regulates collagen3 production. In summary, our study demonstrates that miR-152-5p/Smad3 regulatory pathways involved in fibrotic progression may be a potential therapeutic target of keloids. [BMB Reports 2019; 52(3): 202-207]
Zhu Wenhui,Wu Le,Duan Lei,Xu Shengquan 한국응용곤충학회 2022 Journal of Asia-Pacific Entomology Vol.25 No.1
A preliminary checklist of the ants of northern Shaanxi is presented based on an evaluation from June 2018 to September 2020. Seven species are reported from Shaanxi for the first time: Formica approximans Wheeler, 1933; Formica clara Forel, 1886; Messor aralocaspius (Ruzsky, 1902); Plagiolepis pygmaea (Latreille, 1798); Tapinoma rectinotum Wheeler, 1927; Tetramorium chefketi Forel, 1911; Tetramorium tsushimae Emery, 1925 and Temno thorax ruginosus Zhou, Huang, Yu & Liu, 2010. A new species of genus Proformica Ruzsky, 1902, Proformica muusensis sp. nov., is described based on the morphology and molecular method. In total, three subfamilies with 34 valid ant species in 15 genera are reported in our checklist.