http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : ( Sergey Borovskiy ) (검색결과 2 건)
- 무료
- 기관 내 무료
- 유료
-
( Kulpash Kaliaskarova ),( Yuriy Prokopenko ),( Zhansaya Muratova ),( Sergey Borovskiy ),( Tokan Sultanaliyev ),( Adilbek Mukazhanov ),( Bakhyt Zharkimbekov ),( Assan Zhexembayev ),( Gani Kuttymuratov 대한간학회 2016 춘·추계 학술대회 (KASL) Vol.2016 No.1
Aims: End-stage liver disease represents a major healthcare problem worldwide and in Kazakhstan, carrying a high risk for mortality. Around 1000 patients with end-stage liver disease need liver transplantation in Kazakhstan, more than 50 of them dying yearly without being transplanted. The aim of this paper was review treatment methods for end-stage liver cirrhosis in our center. Methods: Results of various treatment options for end-stage liver disease patients, treated in JSC National Scientific Center for oncology and transplantology since June 2013 so far, were reviewed. Results: Total of 18 liver transplantations, including 6 from cadaveric and 12 from live donors, were performed in our clinic since June 2013, so far. Etiology of liver disease was as follows: HCC (due to nonalcoholic steatohepatitis in 2, hepatitis B in 1) 3 patients, liver cirrhosis (due to alcoholic liver disease in 3, hepatitis C in 2, hepatitis B+D in 6, autoimmune hepatitis in 1, primary biliary cirrhosis in 2 and autoimmune hepatitis and hepatitis B in 1) 14 patients, remaining was 7-year old pediatric patient with biliary atresia. Out of 18 transplanted patients, 2 have succumbed in the early post-operative period due to hemorrhage, remaining 16 are followed-up, counting up to 32 months of disease and rejection-free survival. Since the establishment of hepatology beds at department of general therapy in June 2015, total of 122 patients with liver cirrhosis and hepatocellular carcinoma were treated so far up to February 2016. Methods of treatment of hepatocellular carcinoma included transarterial chemoembolisation used 10 times in 6 patients, 1 patient has succumbed after 3 months of being diagnosed. Treatment options for portal hypertension in 113 liver cirrhosis patients included: esophageal varices ligation and sclerotherapy in 45 patients, splenic artery and esophageal varices embolisation in 22 patients with no complications dated and treatment with beta blockers in the rest of the patients. Out of 113 patients, 1 has succumbed due to the disease progression since start of follow-up in June 2015. Conclusions: Liver transplantation is the only viable option for end-stage liver disease patients. Portal hypertension treatment options using endoscopic and endovascular methods may provide sufficient short-term effect with good safety profile while being waitlisted, thus making liver transplantation available for more patients.
-
( Niyaz Malayev ),( Nariman Tabynbayev ),( Turlybek Tuganbekov ),( Nasrulla Shanazarov ),( Mantas Trakimas ),( Sergey Borovskiy ),( Dmitriy Viderman ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1
Aims: To study the possible applications and uses of various loaded microspheres, based on the morphometric options of the angioarchitecture formations. Methods: We analyzed the results of the morphometric study of three groups of patients with liver metastases. We have studied sectional biopsies of 62 patients with liver metastases from colorectal cancer, stomach cancer and pancreatic cancer aged 45 to 72 years, of whom 44 (70%) men and 18 (30%) women; 16 of them (26%) patients underwent 38 courses of hepatic artery chemoembolization (TACE). The remaining 46 (74%) patients underwent surgical resection of the liver. Diameter formations made from 3 cm to 7 cm.Samples of liver tissue biopsies were fixed in 10% buffered formalin (pH 6,8-7), dehydrated in alcohols of increasing concentrations, embedded in paraffin blocks, sectioned, of which a thickness of 3 -. 5 mcm with followed by staining with hematoxylin and eosin. Each biopsy of the liver was determined by the volume fraction of the vessels of portal tracts, which houses the tumor mass. Histological studies were performed using Axioskop 40 FL microscope at magnification x100, x200, X400. The morphometric study was performed using Axioskop 40 FL microscope with the help of the program Morphometry 5.0. Results: Statistical analysis was performed using the software package STATISTICA 6.1 for Windows and IBM SPSS version 18.0 for Microsoft Windows. Theoretically, we selected the appropriate size of the microspheres loaded with chemotherapy drugs to target chemoembolization. In view of the morphological pattern, we assumed that the smaller the diameter, the more efficiently and will ischemic effects of chemotherapeutic treatments. Morphology of colorectal cancer metastases was presented hypervascular formations with a diameter of vessels from 75,800 ± 7,5432μm, from the center to the periphery of the formations with chaotic arrangement. Metastatic Gastric Cancer 88,829 ± 14,740 μm and pancreas -73,598 ± 11,518 μm, respectively, and were heterogeneous with areas of hyper- and hypo vascularization. Conclusions: The study of vascular architectonics liver cancers has important prognostic value. The method of morphological (histological and morphometric) studies allowed us to determine the diameters of the arteries supplying the metastatic liver tumors. We have found that the range of the average value of the diameter of the arteries metastatic colorectal cancer, 75,800 ± 7,5432 μm, gastric cancer metastasis 88,829 ± 14,740 μm and pancreas -73,598 ± 11,518 μmOur results diameters of arteries of liver metastatic tumors, allow us to recommend the mandatory use of selective miсroс atheter-technology. The results of morphometric studies diameters of arteries liver metastatic tumors are the basis to recommend: metastases in the liver, stomach cancer chemotherapy use saturated calibrated microspheres with a diameter 75μm,and higher, with liver metastases of pancreatic cancer and colorectal cancer - 40μm, and higher.
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
