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( Robertus Satriyo Bs ),( Sugiarto ),( Supriyanto Kartodarsono ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Serum Osteoprotegerin (OPG) is an independently indicator of cardiovascular disease. The serum concentration ratio of triglyceride (TG)/high density lipoprotein cholesterol (HDL-C) also identify cardiovascular disease. The aim of this study is to analyze correlation between OPG and TG/HDL-C ratio in metabolic syndrome (MetS) patients. Methods: A cross sectional study with analytic approach was conducted on Moewardi Hospital, Indonesia in 2013. Forty patients MetS and forty patient non-MetS were recruited from the general medical check-up clinic. Patients were diagnosed metabolic syndrome based on International Diabetes Federation (IDF) 2005 criteria. The differences between variables were compared using independent sample t-test. The relationship between OPG and TG/HDL-C ratio was evaluated by Pearson`s correlation coefficient Results: The patients mean age was 47.7±8.5 years in MetS and 42.6±9.3 years in non-MetS patients, MetS more common in women than in men (27 vs 13). There were statistically significantly differences among parameters: age, TG, OPG, TG/HDL-C ratio (p=0.013, 0.001, 0.002, 0.001 respectively). Mean OPG serum levels higher in MetS than non-MetS (0.73±0.32 vs 0.55±0.17 (pmol/l). MetS patients had higher mean TG/ HDL-C ratio than non-MetS (5.78±4.36 vs 2.76±1.65). Osteoprotegerin signifi cantly correlated with TG/HDL-C ratio in MetS (r= -0.46, p=0.003), but not in non-MetS Conclusions: The OPG was negatively correlated with TG/HDL-C ratio in metabolic syndrome.
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