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Le Linn Yun,Nandhini Srinivasan,Rehena Sultana,N. Gopalakrishna Iyer,Rena Dharmawan 대한내분비외과학회 2023 The Koreran journal of Endocrine Surgery Vol.23 No.4
The treatment of primary hyperparathyroidism (PHPT) has evolved beyond traditional 4-gland exploration to more targeted and less invasive approaches. One such approach is the minimally invasive video-assisted parathyroidectomy (MIVAP). While this has been adopted by several institutions who reported promising results, there have been no assessment of the existing literature of its efficacy and safety. The aim of this study was to compare the outcomes of MIVAP and open surgery for PHPT. We performed a systematic review and meta-analysis of literature comparing outcomes of MIVAP vs. open surgery for PHPT. Forty studies were shortlisted, of which 14 were comparative. Two thousand thirty-five patients underwent MIVAP of mean age 58.6±7.8 years. Mean length of stay (LOS) was 1.83±1.3 days, pain score 1.84±0.69 and satisfaction with cosmesis 8.8±0.63. Bleeding risk was 0.4%, recurrent laryngeal nerve (RLN) injury risk was 1.3%, and no post-operative mortality was reported. Patients who underwent MIVAP had a significant shorter LOS compared to open surgery (mean difference, −0.27; 95% confidence interval, −0.45, −0.10; P=0.002), but had no difference in pain, cosmesis, failure to cure, bleeding, and RLN injury risks. MIVAP is safe and efficacious in treating PHPT, and may be associated with shorter LOS.
( Soon Yaw Walter Wong ),( Fen Li Stephanie Ler ),( Rehena Sultana ),( Hamid Rahmatullah Bin Abd Razak ) 대한슬관절학회 2022 대한슬관절학회지 Vol.34 No.-
Purpose: Asians have a low venous thromboembolism (VTE) incidence following total knee arthroplasty (TKA). This systematic review and network meta-analysis was conducted to evaluate the best prophylaxis against VTE in Asians following total knee arthroplasty in current literature. Materials and Methods: A systematic search of PubMed, Embase and CINAHL was conducted in adherence with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Prophylaxis types were separated into low-molecular-weight heparin (LMWH), novel oral anti-coagulants (NOAC), mechanical-only prophylaxis (MOP) and no prophylaxis (NP). The primary outcome was VTE incidence, grouped according to diagnosis modality (ultrasound, venography, clinical). The secondary outcome was bleeding incidence, grouped into minor and major bleeding. Results: Fourteen eligible articles, totalling 4259 patients, were pooled with the following significant results: NOACs had lower venography-diagnosed VTE incidence than LMWH (12.77%, p = 0.02) and NP (20.64, p < 0.001). MOP had lower venography-diagnosed VTE incidence than LMWH (23.72%, p < 0.001), NOACs (10.95%, p < 0.001) and NP (31.59%, p < 0.001) but, interestingly, a statistically higher ultrasound-diagnosed VTE incidence than LMWH (6.56%, p = 0.024) and NP (4.88%, p = 0.026). No significant differences were observed between prophylaxis types for symptomatic VTE, pulmonary embolism (PE) or death. LMWH and NOACs had a higher minor bleeding incidence than NP (11.71%, p < 0.001 and 6.33%, p < 0.02, respectively). No significant differences were observed between prophylaxis types for major bleeding incidence. Conclusion: NOACs are a superior form of chemoprophylaxis, compared with LMWH, in reducing venographydiagnosed VTE incidence with no added bleeding incidence. However, routine chemoprophylaxis may not be required as LMWH and NOACs do not appear to reduce symptomatic VTE incidence compared with MOP and NP with an increased minor bleeding incidence. Mechanical prophylaxis in the form of graduated compression stockings or intermittent pneumatic compression should be routinely considered with significantly lower rates of venography-diagnosed VTE compared with NP. On the basis of current evidence, we recommend an individualised approach to select the most appropriate prophylaxis type.