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- 저자 : ( Prakash Khanal ) (검색결과 2 건)
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Biradar Prakash,Patil Vishal Supda,Joshi Hanumanthachari,Khanal Pukar,Mallapur Shamanand 경희대학교 융합한의과학연구소 2022 Oriental Pharmacy and Experimental Medicine Vol.22 No.1
This paper aimed to elucidate the effect of Erythrina variegata L. bark on scopolamine-induced memory impairment in rats and to decipher the molecular mechanism of phytoconstituents via the utilization of gene set enrichment analysis, network pharmacology coupled with in silico docking study. First, three models i.e. Morris Water Maze (MWM), Elevated Plus Maze (EPM), and Passive Avoidance Paradigm (PA) were utilized to elucidate the memory function. Second, the level of biomarkers i.e. acetylcholinesterase enzyme, reduced glutathione, and lipid peroxidation level were measured in brain tis- sues. Third, the key bioactive phytoconstituents targeting potential protein targets and pathways were identified through gene set enrichment analysis and network pharmacology. Lastly, the interaction between bioactive phytoconstituents with their respective targets was confirmed by molecular docking analysis. The MWM, EPM, and PA activity showed, scopolamine administration increased Escape Latency Time (ELT), Transfer Latency (TL), and Step Through Latency (STL) respectively on day 0th, 7th, 14th, and 21st, whereas treatment with E. variegata extract significantly reverse the ELT, TL and STL activ- ity. The decreased level of Acetylcholinesterase (AChE) and MDA level in treated animals reflected the enhanced memory and was found to be comparable withclinically proven drug i.e. donepezil. Sixty compounds were identified in EV bark, among which twenty-two compounds are predicted to modulate potential targets involved in AD and considered potentially bioactive. Further, the docking study revealed, Alpinumisoflavone, Auriculatin, Osajin, and Scandenone to have the highest binding affinity with Tau protein, Whereas Donepezil and Glucoerysodine with acetylcholinesterase enzyme.
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( Suresh Jaiswal ),( Abhishek Lamichhane ),( Dipa Kusi ),( Man Bahadur Khatri ),( Prakash Khanal ) 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1
Aims: HIV is the chronic viral infection documented worldwide and HCV infection in HIV is a major infection. C-reactive protein is one of the acute-phase protein used as biomarker of inflammation. CRP is hepatic in origin which increases their concentrations during certain inflammatory disorders. CRP levels in human serum are normally quite low (around 1μl/mL), but it increases several hundred folds during the acute-phase inflammation. Methods: A Case control study was carried out in 244 participants including 122 HCV infected HIV and 122 non-infected (healthy) individuals for the comparison of CRP concentration using Nephelometry method by MISPA i2. The blood samples for case were taken from ART center of Western regional hospital and for control samples were taken from Pokhara valley through counseling and Questionnaires and ethical permission was obtained from IRC. Results: Among the 122 HCV infected participants 16(13.11%) individuals had CRP concentration >6mg/L and healthy 122 participants only 2(1.63%) participants had CRP concentration >6mg/L bearing of positive prevalence rate. This showed the significance level of P=0.001 and OR=9.057 with nine fold higher prevalence in the case and control. Male participant were found to have higher level of CRP (>6mg/L) in case, among 16 CRP positive, 9(7.4%) were male and 7(5.7%) were female. In control equal prevalence of positive CRP concentration (>6mg/L) was sheen between male and female 1(.8%). The sex wise distribution showed no significance with the CRP level. The mean CRP concentration in HIV infected participants was 2.07mg/L and in non-infected (healthy) participants was 1.40mg/L. Conclusions: Highest prevalence of the positive CRP concentration was among the case in our study which might be due to the defect in immune system of HCV-HIV infected individuals than of healthy individuals.
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