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Cord blood banking-Where to Now?
( Paul Fogarty ) 대한산부인과학회 2015 대한산부인과학회 학술대회 Vol.101 No.-
Cord blood contains many different types of cells including very slllall numbers of a p:lrticu]ar type of cell, known as stem cells. Cord blood stem cells are currently used in the treatment of: blood related disorders, such as leukaemia, haemoglobinopathies and some immune system and metabolic storage disorders. Some scientists have claimed thai cord blood could also potentially be used to cure diseases such as Alzheimer``s disease. Parkinson``s disease and conditions such as diabetes On the other hand others argue that there is not enough evidence to back up these claims. It may be that in the fulure morc diseases will be treated with cord blood. At present, however, much more research is needed. Evidence Based medicine has rightly become the corner slone of good practice for clinical staff and organisations yet our patients are eaSily mislead by exaggerated claims particularly form the Private sector This talk will look at the t),pes of cord Blood banking a\``ailable. The evidence base around the place of Cord Blood Banking will be reviewed along with the RCOG recommendations for Patients, Units and Individuals
Genome editing reveals a role for OCT4 in human embryogenesis
Fogarty, Norah M. E.,McCarthy, Afshan,Snijders, Kirsten E.,Powell, Benjamin E.,Kubikova, Nada,Blakeley, Paul,Lea, Rebecca,Elder, Kay,Wamaitha, Sissy E.,Kim, Daesik,Maciulyte, Valdone,Kleinjung, Jens,K Macmillan Publishers Limited, part of Springer Nat 2017 Nature Vol.550 No.7674
<P>Despite their fundamental biological and clinical importance, the molecular mechanisms that regulate the first cell fate decisions in the human embryo are not well understood. Here we use CRISPR-Cas9-mediated genome editing to investigate the function of the pluripotency transcription factor OCT4 during human embryogenesis. We identified an efficient OCT4-targeting guide RNA using an inducible human embryonic stem cell-based system and microinjection of mouse zygotes. Using these refined methods, we efficiently and specifically targeted the gene encoding OCT4 (POU5F1) in diploid human zygotes and found that blastocyst development was compromised. Transcriptomics analysis revealed that, in POU5F1-null cells, gene expression was downregulated not only for extra-embryonic trophectoderm genes, such as CDX2, but also for regulators of the pluripotent epiblast, including NANOG. By contrast, Pou5f1-null mouse embryos maintained the expression of orthologous genes, and blastocyst development was established, but maintenance was compromised. We conclude that CRISPR-Cas9-mediated genome editing is a powerful method for investigating gene function in the context of human development.</P>