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Fabio Grizzi,Gianluigi Taverna,Piergiuseppe Colombo,Mauro Seveso,Guido Giusti,Silvia Proietti,Girolamo Fiorini,Giovanni Lughezzani,Paolo Casale,Nicolò Buffi,Massimo Lazzari,Giorgio Guazzoni 대한비뇨의학회 2015 Investigative and Clinical Urology Vol.56 No.6
Purpose: Prostate cancer is the most frequent cancer in men in Europe. A major focus in urology is the identification of new biomarkerswith improved accuracy in patients with low-risk prostate cancer. Here, we evaluated two-dimensional neovascular complexityin prostate tumor and nontumor biopsy cores by use of a computer-aided image analysis system and assessed the correlationsbetween the results and selected clinical and pathological parameters of prostate carcinoma. Materials and Methods: A total of 280 prostate biopsy sections from a homogeneous series of 70 patients with low-risk prostatecancer (Gleason score 3+3, prostate-specific antigen [PSA]<10 ng/mL, and clinical stage T1c) who underwent systematic biopsysampling and subsequent radical prostatectomy were analyzed. For each biopsy, 2-μm sections were treated with CD34 antibodiesand were digitized by using an image analysis system that automatically estimates the surface fractal dimension. Results: Our results showed that biopsy sections without cancer were significantly more vascularized than were tumors. No correlationswere found between the vascular surface fractal dimension and patient's age, PSA and free-to-total PSA ratios, pathologicalstage, Gleason score, tumor volume, vascular invasion, capsular penetration, surgical margins, and biochemical recurrence. Conclusions: The value of angiogenesis in prostate cancer is still controversial. Our findings suggest that low-risk prostate cancertissues are less vascularized than are nontumor tissues. Further studies are necessary to understand whether angiogenesis is a hallmarkof intermediate- and high-risk prostate cancer.
The Impact of Intrapericardial versus Intrapleural HeartMate 3 Pump Placement on Clinical Outcomes
Michael Salna,Yuming Ning,Paul Kurlansky,Melana Yuzefpolskaya,Paolo C. Colombo,Yoshifumi Naka,Koji Takeda 대한심장혈관흉부외과학회 2022 Journal of Chest Surgery (J Chest Surg) Vol.55 No.3
Background: The integrated design of the HeartMate 3 (Abbott Laboratories, Chicago, IL, USA) affords flexibility to place the pump within the pericardium or thoracic cavity. We sought to determine whether the presence of a left ventricular assist device (LVAD) in either location has a meaningful impact on overall patient outcomes. Methods: A retrospective cohort study was conducted of all 165 patients who received a HeartMate 3 LVAD via a median sternotomy from November 2014 to August 2019 at our center. Based on operative reports and imaging, patients were divided into intrapleural (n=81) and intrapericardial (n=84) cohorts. The primary outcome of interest was in-hospital mortality, while secondary outcomes included postoperative complications, cumulative readmission incidence, and 3-year survival. Results: There were no significant between-group differences in baseline demographics, risk factors, or preoperative hemodynamics. The overall in-hospital mortality rate was 6%, with no significant difference between the cohorts (9% vs. 4%, p=0.20). There were no significant differences in the postoperative rates of right ventricular failure, kidney failure requiring hemodialysis, stroke, tracheostomy, or arrhythmias. Over 3 years, despite similar mortality rates, intrapleural patients had significantly more readmissions (n=180 vs. n=117, p<0.01) with the most common reason being infection (n=68/165), predominantly unrelated to the device. Intrapleural patients had significantly more infection-related readmissions, predominantly driven by non-ventricular assist device-related infections (p=0.02), with 41% of these due to respiratory infections compared with 28% of intrapericardial patients. Conclusion: Compared with intrapericardial placement, insertion of an intrapleural HM3 may be associated with a higher incidence of readmission, especially due to respiratory infection.