http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Novel nuclear localization signal regulated by ambient tonicity in vertebrates.
Kwon, Min Seong,Lee, Sang Do,Kim, Jeong-Ah,Colla, Emanuela,Choi, Yu Jeong,Suh, Pann-Ghil,Kwon, H Moo American Society for Biochemistry and Molecular Bi 2008 The Journal of biological chemistry Vol.283 No.33
<P>TonEBP is a Rel domain-containing transcription factor implicated in adaptive immunity, viral replication, and cancer. In the mammalian kidney, TonEBP is a central regulator of water homeostasis. Animals deficient in TonEBP suffer from life-threatening dehydration due to renal water loss. Ambient tonicity (effective osmolality) is the prominent signal for TonEBP in a bidirectional manner; TonEBP activity decreases in hypotonicity, whereas it increases in hypertonicity. Here we found that TonEBP displayed nuclear export in response to hypotonicity and nuclear import in response to hypertonicity. The nuclear export of TonEBP was not mediated by the nuclear export receptor CRM1 or discrete nuclear export signal. In contrast, a dominant nuclear localization signal (NLS) was found in a small region of 16 amino acid residues. When short peptides containing the NLS were fused to constitutively cytoplasmic proteins, the fusion proteins displayed tonicity-dependent nucleocytoplasmic trafficking like TonEBP. Thus, tonicity-dependent activation of the NLS is crucial in the nucleocytoplasmic trafficking of TonEBP. The novel NLS is present only in the vertebrates, indicating that it developed late in evolution.</P>
Poster Session : Regulation of blood glucose by Lysophosphatidylcholine
( Kyung Moo Yea ),( Jae Yoon Kim ),( Tae Wan Kwon ),( Jong Hyun Kim ),( Byoung Dae Lee ),( Seung Je Lee ),( Ho Sean Park ),( Tae Hoon Lee ),( Kyong Soo Park ),( Pann Ghil Suh ),( Sung Ho Ryu ) 생화학분자생물학회 2006 생화학분자생물학회 춘계학술발표논문집 Vol.2006 No.-