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Jeong, Jin-Ok,Kim, Jeong-Hee,Ahn, Kye-Taek,Park, Hyung Seo,Jang, Won Il,Park, Jae-Hyeong,Lee, Jae-Hwan,Choi, Si Wan,Kim, Jin Man,Seong, In-Whan The Korean Society of Cardiology 2010 Korean Circulation Journal Vol.40 No.11
<P><B>Background and Objectives</B></P><P>Vascular smooth muscle cell (VSMC) proliferation is responsible for the restenosis of previously inserted coronary stents. Angiotensin II (Ang II) is known to regulate VSMC proliferation. LKB1, a serine/threonine kinase, interacts with the p53 pathway and acts as a tumor suppressor.</P><P><B>Materials and Methods</B></P><P>We assessed the association of Ang II and the expression of LKB1 in primary cultured murine VSMCs and neointima of the Sprague Dawley rat carotid artery injury model. We created carotid balloon injuries and harvested the injured carotid arteries 14 days after the procedure.</P><P><B>Results</B></P><P>Ang II increased LKB1 expression in a time-dependent manner and peaked at an Ang II concentration of 10<SUP>-7</SUP> mole/L in VSMCs. In the animal experiment, neointima was markedly increased after balloon injury compared to the control group. Immunohistochemical studies showed that LKB1 expression increased according to neointima thickness. Ang II augmented LKB1 expression after the injury. Western blot analysis of LKB1 with carotid artery lysate revealed the same pattern as LKB1 immunohistochemistry. Increased LKB1 expression started at 5 days after the balloon injury, and peaked at 14 days after the injury. Although LKB1 expression was increased after the injury, LKB1 kinase activity was not increased. Ang II or balloon-injury increased the expression of LKB1 although the LKB1 activity was reduced.</P><P><B>Conclusion</B></P><P>Ang II increased LKB1 expression in VSMCs and neointima. These findings were not kinase dependant.</P>
Jeong, Lak Shin,Yoo, Su Jeong,Lee, Kang Man,Koo, Mi Jeong,Choi, Won Jun,Kim, Hea Ok,Moon, Hyung Ryong,Lee, Min Young,Park, Jae Gyu,Lee, Sang Kook,Chun, Moon Woo 梨花女子大學校 藥學硏究所 2003 藥學硏究論文集 Vol.- No.12
Fluoroneplanocin A (12) was designed as a novel mechanism-based inhibitor of S-adenosylhomocysteine hydrolase (SAH) and efficiently synthesized via an electrophilic vinyl fluorination reaction (n-BuLi, N-fluorobenzenesulfonimide at -78℃). Fluoroneplanocin A exhibited 2-fold more potent SAH Inhibitory activity than the parent neplanocin A. A new mechanism of irreversible Inhibition discovered in this work might provide new alternatives in the design of a different class of antiviral agents operating via SAH inhibition.
Epigallocatechin-3-Gallate Has an Anti-Platelet Effect in a Cyclic AMP-Dependent Manner
Ok, Woo-Jeong,Cho, Hyun-Jeong,Kim, Hyun-Hong,Lee, Dong-Ha,Kang, Hye-Yeon,Kwon, Hyuk-Woo,Rhee, Man Hee,Kim, Mujo,Park, Hwa-Jin Japan Atherosclerosis Society 2012 Journal of atherosclerosis and thrombosis Vol.19 No.4
<P>Aim: In this study, we investigated the effect of (−)-epigallocatechin-3-gallate (EGCG) on cyclic nucleotide production and vasodilator-stimulated phosphoprotein (VASP) phosphorylation in collagen (10 µg/mL)-stimulated platelet aggregation.Methods: Washed platelets (10<SUP>8</SUP>/mL) from Sprague-Dawley rats (6-7 weeks old, male) were preincubated for 3 min at 37°C in the presence of 2 mM exogenous CaCl<SUB>2</SUB> with or without EGCG or other materials, stimulated with collagen (10 µg/mL) for 5 min, and then used for the determination of intracellular cytosolic Ca<SUP>2+</SUP> ([Ca<SUP>2+</SUP>]<SUB>i</SUB>), thromboxane A<SUB>2</SUB> (TXA<SUB>2</SUB>), adenosine 3',5'-cyclic monophosphate (cAMP), guanosine 3',5'-cyclic monophosphate (cGMP), and VASP phosphorylation.Results: EGCG dose-dependently inhibited collagen-induced platelet aggregation by inhibiting both [Ca<SUP>2+</SUP>]<SUB>i</SUB> mobilization and TXA<SUB>2</SUB> production. Of two aggregation-inhibiting molecules, cAMP and cGMP, EGCG significantly increased intracellular levels of cAMP, but not cGMP. EGCG-elevated cAMP level was decreased by SQ22536, an adenylate cyclase inhibitor, but not by etazolate, a cAMPspecific phosphodiesterase inhibitor. In addition, EGCG elevated the phosphorylation of VASP-Ser<SUP>157</SUP>, a cAMP-dependent protein kinase (A-kinase) substrate, but not the phosphorylation of VASP-Ser<SUP>239</SUP>, a cGMP-dependent protein kinase substrate, in intact platelets and collagen-induced platelets, and VASP-Ser<SUP>157</SUP> phosphorylation by EGCG was inhibited by both an adenylate cyclase inhibitor SQ22536 and an A-kinase inhibitor Rp-8-Br-cAMPS. We have demonstrated that EGCG increases cAMP <I>via</I> adenylate cyclase activation and subsequently phosphorylates VASP-Ser<SUP>157</SUP> through A-kinase activation to inhibit [Ca<SUP>2+</SUP>]<SUB>i</SUB> mobilization and TXA<SUB>2</SUB> production on collagen-induced platelet aggregation.Conclusions: These results strongly indicate that EGCG is a beneficial compound elevating cAMP level in collagen-platelet interaction, which may result in the prevention of platelet aggregation-mediated thrombotic diseases.</P>
Jeong, Jin-Ok,Han, Ji Woong,Kim, Jin-Man,Cho, Hyun-Jai,Park, Changwon,Lee, Namho,Kim, Dong-Wook,Yoon, Young-Sup Ovid Technologies Wolters Kluwer -American Heart A 2011 Circulation research Vol.108 No.11
<P>Bone marrow (BM)-derived mesenchymal stem cells (MSCs) hold great promise for cardiovascular cell therapy owing to their multipotency and culture expandability.</P>
Jeong, Lak Shin,Park, Jae Gyu,Choi, Won Jun,Moon, Hyung Ryong,Lee, Kang Man,Kim, Hea Ok,Kim, Hee-Doo,Chun, Moon Woo,Park, Hea-Young,Kim, Kilhyoun,Sheen, Yhun Y. 梨花女子大學校 藥學硏究所 2003 藥學硏究論文集 Vol.- No.12
Novel halovinyl analogues of neplanocin A without 4'-hydroxymethyl group were easily synthesized starting from D-ribose via cyclopentenone 5 as a key intermediate and their inhibitory activity against SAH hydrolase was assayed.
Asymmetric Synthesis of Cyclopropyl-fused 2'-C-Methylcarbanucleosides as Potential Anti-HCV Agents
Jeong, Lak Shin,Lee, Jeong A.,Kim, Hea Ok,Tosh, Dilip K.,Moon, Hyung Ryong,Lee, Seung-Jin,Lee, Kang Man,Sheen, Yhun Y.,Chun, Moon Woo Taylor Francis 2007 NUCLEOSIDES NUCLEOTIDES AND NUCLEIC ACIDS Vol. No.
<P> Novel 2 '-C-methyl-cyclopropyl-fused carbocyclic nucleosides as potential anti-HCV agents were stereoselectively synthesized, utilizing regioselective cleavage of the isopropylidene group and cyclic sulfate chemistry as key steps.</P>
Synthesis And Anti-Hcv Activity Of 2''-&bgr;-Hydroxymethylated Nucleosides
Jeong, Lak Shin,Yoo, Byul Nae,Kim, Hea Ok,Lee, Kang Man,Moon, Hyung Ryong Taylor Francis 2007 Nucleosides, nucleotides & nucleic acids Vol.26 No.6
<P> Synthesis of 2' -&bgr;-hydroxymethyl nucleosides 3-6 was accomplished, using stereoselective hydroxymethylation as a key step. Adenine nucleoside 3 showed potent anti-HCV activity, implying that 2' -&bgr;-hydroxymethyl group has the appropriate electronic properties interfering with HCV polymerase.</P>
Jeong, Lak Shin,Moon, Hyung Ryong,Park, Jae Gyu,Shin, Dae Hong,Choi, Won Jun,Lee, Kang Man,Kim, Hea Ok,Chun, Moon Woo,Kim, Hee-Doo,Kim, Joong Hyup 梨花女子大學校 藥學硏究所 2003 藥學硏究論文集 Vol.- No.12
Halogenated analogues of neplanocin A were synthesized from the key intermediate 1, among which fluoro-neplanocin A was found to be novel mechanism-based irreversible inhibitor of S-Adenosylhomocysteine hydrolase.
Molecular Cloning and Expression of DMRT Gene in Protogynous Wrasse, Halichoeres tenuispinis
Jeong Hyung-Bok,Park Ji-Gweon,Park Jin-Young,Jin Young-Jun,Yang Myung-Cheon,Hyun Kyung-Man,Kim Gi-Ok,Kim Se-Jae 한국발생생물학회 2003 한국발생생물학회 학술발표대회 Vol.2003 No.1
The sex differentiation of fishes occurs under the control of genetic and various environmental factors. DM-domain containing genes are novel zinc finger transcription factors and play key roles in sex determination. In order to isolate the wrasse DMRT (wDMRT) cDNA from the protogynous wrasse (Halichoeres tenuispinnis), the wrasse testis cDNA library was screened using the P-labeled PCR products, which were amplified with the degenerate primers from conserved DM-domain regions of several DMRT genes. Among a few positives obtained through screening, the full length wDMRT cDNA of 2.9kb size encoding a predicted 300 amino acid residues was isolated. The sequence analysis exhibited 60%, 43% sequence identity with rainbow trout and tilapia DMRT1, respectively. RT-PCR assay showed that wDMRT was expressed specifically in male testis. Also, wDMRT gene was strongly expressed in May during reproductive season, when the reproductivity of wrasse is most active. This results suggested that wDMRT gene function in testis differentiation The conserved DM-domain regions were amplified using PCR from DMRT genes of several species among Labridae, and their sequences were determined. The sequence of DM-domain region of Halichoeres. tenuispinis was identical to those of Pseudolabrus japonicus, Pteragogus flagellifera, and showed 94% identity with that of Halichoeres poecioptrerus.