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RISS 인기검색어
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- 저자 : ( Noritaka Takatsu ) (검색결과 2 건)
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( Akihiro Koga ),( Toshiyuki Matsui ),( Noritaka Takatsu ),( Yasumichi Takada ),( Masahiro Kishi ),( Yutaka Yano ),( Takahiro Beppu ),( Yoichiro Ono ),( Kazeo Ninomiya ),( Fumihito Hirai ),( Takashi N 대한장연구학회 2018 Intestinal Research Vol.16 No.2
Background/Aims: Decreased trough levels of infliximab (TLI) and antibodies to infliximab (ATI) are associated with loss of response (LOR) in Crohn’s disease. Two prospective studies were conducted to determine whether TLI or ATI better correlates with LOR (Study 1), and whether TLI could become a predictor of mucosal healing (MH) (Study 2). Methods: Study 1 was conducted in 108 patients, including those with LOR and remission to compare ATI and TLI in discriminating the 2 conditions based on receiver operating characteristic (ROC) curve analyses. Study 2 involved 35 patients who were evaluated endoscopi cally. Results: In Study 1, there were no differences between the 2 assays in ROC curve analyses; the TLI cutoff value for LOR was 2.6 μg/mL (sensitivity, 70.9%; specificity, 79.2%), and the ATI cutoff value was 4.9 μg/mL (sensitivity, 65.5%; specificity, 67.9%). The AUROC (area under the ROC curve) of TLI was greater than that of ATI. AUROC was useful for discriminating be tween the 2 conditions. In Study 2, the TLI was significantly higher in the colonic MH group than in the non-MH group (2.7 μg/mL vs. 0.5 μg/mL, P=0.032). Conclusions: TLI is better than ATI for clinically diagnosing LOR, and a correlation was observed between TLI and colonic MH. (Intest Res 2018;16:223-232)
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Risk factors for severity of colonic diverticular hemorrhage
Ken Kinjo,Toshiyuki Matsui,Takashi Hisabe,Hiroshi Ishihara,Toshiki Kojima,Kenta Chuman,Shigeyoshi Yasukawa,Tsuyoshi Beppu,Akihiro Koga,Satoshi Ishikawa,Masahiro Kishi,Noritaka Takatsu,Fumihito Hirai,K 대한장연구학회 2018 Intestinal Research Vol.16 No.3
Background/Aims: Colonic diverticular hemorrhage (DH) was a rare disease until the 1990s, and its incidence has increased rapidly since 2000 in Japan. In recent years, colonic DH has been the most frequent cause of lower gastrointestinal bleeding (LGIB). Nearly all cases of DH are mild, with the bleeding often stopping spontaneously. Some cases, however, require surgery or arterial embolization. In this study, using a cohort at Fukuoka University Chikushi Hospital, we investigated factors associated with severe colonic DH. Methods: Among patients with LGIB who underwent colonoscopy at our hospital between 1995 and 2013, DH was identified in 273 patients. Among them, 62 patients (22.7%) were defined as having severe colonic DH according to recurrence of bleeding in a short period, and/or the necessity of transfusion, arterial embolization, or surgery. We then evaluated risk factors for severe DH among DH patients in this retrospective cohort. Results: Among the 273 patients with DH, use of non-steroidal anti-inflammatory drugs (NSAIDs) (odds ratio [OR], 2.801; 95% confidence interval [CI], 1.164–6.742), Charlson Risk Index (CRI) ≥2 (OR, 3.336; 95% CI, 1.154–7.353), right-sided colonic DH (OR, 3.873; 95% CI, 1.554–9.653), and symptoms of cerebral hypoperfusion (such as light-headedness, dizziness, or syncope) (OR, 2.926; 95% CI, 1.310–6.535) showed an increased risk of severe DH even after controlling for other factors. Conclusions: Severe DH occurred in 23% of DH patients, and NSAID use, CRI ≥2, right-sided colonic DH, and symptoms of cerebral hypoperfusion are suggested to be predictors of severe DH.
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