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AQUATIDE Plays a Role as Innovative Skin-Care Vaccine Through The Autophagy Induction
( Chaejin Lim ),( Myungho Kor ),( Seokjeong Yoon ),( Heungjae Kim ),( Kyungho Park ),( Keedon Park ) 한국피부장벽학회 2016 한국피부장벽학회지 Vol.18 No.2
Natural moisturizing factor (NMF) in the stratum corneum has a high moisture retaining efficacy, and plays a major role in the skin barrier function. Pyrrolidone carboxylic acid (PCA) is one of the major NMFs found in human skin. Aquatide, a PCA-mimetic peptide, improves the skin barrier function by stimulating filaggrin expression as well as reducing Trans-Epidermal Water Loss (TEWL) correlated with increased water retention and moisturization. Autophagy is the natural destructive mechanism that allows the orderly degradation and recycling of cellular damaged components. So, Increased autophagy delays ageing process and extends longevity. Sirtuin1 (SIRT1) is a nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase functioning in the regulation of metabolism, cell survival and organismal lifespan. AQUATIDE alleviates ROS- and heavy metal-mediated senescence and cytotoxicity of cells by SIRT1-dependent autophagy. Furthermore, AQUATIDE reduces pollen-mediated PGE2 release and keeps the skin healthy during an allergic reaction against pollen treatment. In conclusion, AQUATIDE is considered as the first needle-free “skin-care vaccine” for various troubled skins including inflamed and irritated skin as well as aged skin.
Aquatide Activation of SIRT1 Reduces Cellular Senescence through a SIRT1-FOXO1-Autophagy Axis
( Chae Jin Lim ),( Yong-moon Lee ),( Seung Goo Kang ),( Hyung W. Lim ),( Kyong-oh Shin ),( Se Kyoo Jeong ),( Yang Hoon Huh ),( Suin Choi ),( Myungho Kor ),( Ho Seong Seo ),( Byeong Deog Park ),( Keedo 한국응용약물학회 2017 Biomolecules & Therapeutics(구 응용약물학회지) Vol.25 No.5
Ultraviolet (UV) irradiation is a relevant environment factor to induce cellular senescence and photoaging. Both autophagy- and silent information regulator T1 (SIRT1)-dependent pathways are critical cellular processes of not only maintaining normal cellular functions, but also protecting cellular senescence in skin exposed to UV irradiation. In the present studies, we investigated whether modulation of autophagy induction using a novel synthetic SIRT1 activator, heptasodium hexacarboxymethyl dipeptide-12 (named as Aquatide), suppresses the UVB irradiation-induced skin aging. Treatment with Aquatide directly activates SIRT1 and stimulates autophagy induction in cultured human dermal fibroblasts. Next, we found that Aquatide-mediated activation of SIRT1 increases autophagy induction via deacetylation of forkhead box class O (FOXO) 1. Finally, UVB irradiation-induced cellular senescence measured by SA-β-gal staining was significantly decreased in cells treated with Aquatide in parallel to occurring SIRT1 activation-dependent autophagy. Together, Aquatide modulates autophagy through SIRT1 activation, contributing to suppression of skin aging caused by UV irradiation.
Aquatide Activation of SIRT1 Reduces Cellular Senescence through a SIRT1-FOXO1-Autophagy Axis
Lim, Chae Jin,Lee, Yong-Moon,Kang, Seung Goo,Lim, Hyung W.,Shin, Kyong-Oh,Jeong, Se Kyoo,Huh, Yang Hoon,Choi, Suin,Kor, Myungho,Seo, Ho Seong,Park, Byeong Deog,Park, Keedon,Ahn, Jeong Keun,Uchida, Yos The Korean Society of Applied Pharmacology 2017 Biomolecules & Therapeutics(구 응용약물학회지) Vol.25 No.5
Ultraviolet (UV) irradiation is a relevant environment factor to induce cellular senescence and photoaging. Both autophagy- and silent information regulator T1 (SIRT1)-dependent pathways are critical cellular processes of not only maintaining normal cellular functions, but also protecting cellular senescence in skin exposed to UV irradiation. In the present studies, we investigated whether modulation of autophagy induction using a novel synthetic SIRT1 activator, heptasodium hexacarboxymethyl dipeptide-12 (named as Aquatide), suppresses the UVB irradiation-induced skin aging. Treatment with Aquatide directly activates SIRT1 and stimulates autophagy induction in cultured human dermal fibroblasts. Next, we found that Aquatide-mediated activation of SIRT1 increases autophagy induction via deacetylation of forkhead box class O (FOXO) 1. Finally, UVB irradiation-induced cellular senescence measured by $SA-{\beta}-gal$ staining was significantly decreased in cells treated with Aquatide in parallel to occurring SIRT1 activation-dependent autophagy. Together, Aquatide modulates autophagy through SIRT1 activation, contributing to suppression of skin aging caused by UV irradiation.